Healing Flashcards
Regeneration
Tissue is replaced from parenchyma by cell division (mitosis)
Labor tissue
Divides continuously to replace cells that are constantly being depleted Ex: Epithelia of skin Mucous membranes Lining of various ducts Red bone marrow and lymphoid tissues
Stable tissue
Cells divide but only slowly beyond adolescence when normal development is complete
Cells are able to function throughout life, so that high mitosis rates are not normally required
Rate increases when damages tissue must be replaced
Ex:
Glands
Osteoblasts
Smooth muscle fibers
Vascular epithelium
Permanent tissue
After birth lose all mitotic ability Loss of which results in functional loss Cells lost are replaced by scar tissue Ex: Nervous tissue Cardiac and skeletal muscles
Tissue repair
Fibrous scar tissue fills the gaps left by the loss of damaged tissue
Fibrous connective tissue restores strength and structural integrity of damaged tissue that cannot regenerate
Fibrosis
Formation of collagen fibers
Fibroblasts present in stroma
Formation starts with the secretion of pro-collagen, fundamental subunit
Enzymatically altered to form long filaments of collagen
Filaments join together to form thicker collagen fibers, which in turn are grouped into collagen fiber bundle
Revascularization
Angiogenesis (formation of new blood vessels)
Occurs in loosely gelled protein rich exudates
Granulation tissue
Surface restoration
Restore the protective epithelium that covers body and organ surfaces
Primary healing
Healing of incision or severing wound of the skin
Secondary healing
Wound edges are not closely apposed
Contracture
Newly formed college and demonstrates an exaggerated wound contraction
Adhesions
Joining of serous membrane’s restriction of movement in structures
Dehiscence
Breaking open of a healing wound possibly due to pressure on the wound
Keloids
Irregular masses of scar tissue you that protrude from the surface of skin which results from the overproduction of dermal college in during healing transforming growth factor beta TFG beta
Stricture
Narrowing of lumen of organ , a complication of contracture
Ex hour glass stomach
