Helminths: Pathogenesis and Defenses Flashcards
(70 cards)
transmission of infection
- accidental ingestion of eggs or larvae
- larvae penetrate skin
- requires intermediate host vector
helminths that infect through ingestion
- Ascaris
- Echinococcus
- Enterobius
- Trichuris
- Hookworms (larvae)
helminths that infect through skin penetration
- Hookworms
- Schistosomes
- Strongyloides
helminths that infect via intermediate host vector
- Filarial worms via arthorpod vectors
- Clonorchis in fish
- tapeworms in meat and fish
- Trichinella in meat
Entry of pathogenic helminths
- mouth
- bite of insect vector
- penetration
entry via mouth
eggs or larvae in water, food, or intermediate host
entry via bite of insect vector
larvae enter skin
entry via penetration
larvae burrow through skin
localization of pathogenic helminths
- internal organs
- intestine
- dermal and lymphatic tissues
- blood vessels
internal organs
- liver
- lungs
- CNS
blood vessels
around intestine or bladder
major factor influencing susceptibility to infection
human behavior
where is the level of infection directly related to
number of infective stages encountered
does every exposure result in the development of a mature infection?
no
what kills infective organisms
host’s nonspecific defense mechanism
what does the number of worms present represent
dynamic balance between:
- rate of infection
- efficiency of defense
how do individuals differ in their ability to resist infection
genetically
what may affect susceptibility
changes in diet
immunosuppressive therapies
- irradiation
- immunosuppressant drugs
what offsets the ability of hosts to control infection
ability of parasites to avoid host’s defenses and increase their survival
worms athat are unaffected by the host’s attempts to limit or destroy them due to them being large and mobile
- Ascaris
- hookworms
- hydatid cysts
- Trichuris
- tapeworms
where do pathogenic consequences relate to
- size
- movement
- longevity of parasites
- host’s exposure to long-term damage and immune stimulation
- sheer physical consequences of being inhabited by large foreign bodies
different types of damage
- direct damage from worm activity and large helminths
- indirect damage from host response
direct damage
- blockage of internal organs
- pressure exerted by growing parasites