Hematology Cliff Notes

Question 0

Low MCV, RDW normal, normal or high RBC count

Answer 0

Thalassemia

Question 1

Low MCV, high RDW, low serum iron, High retic

Answer 1

Iron deficiency

Question 2

Stippled RBC

Answer 2

Lead poisoning Sideroblastic anemia

Question 3

Low MCV, high serum iron

Answer 3

Alcoholism or other liver disease

Question 4

High MCV in newborn

Answer 4

Normal condition

Question 5

High MCV with hypersegmented neutrophils, high RDW, ovalocytes

Answer 5

B12 for folic acid deficiency megaloblastic anemia

Question 6

Positive schilling test

Answer 6

B12 deficiency

Question 7

Anemia with low retic and low WBC, low platelets

Answer 7

Aplastic anemia or chemotherapy

Question 8

Anemia with decreased haptoglobin

Answer 8

Intravascular hemolysis (transfusion reaction, PCH, autoimmune hemolytic anemia, etc.)

Question 9

Anemia with increased serum bilirubin

Answer 9

Extravascular hemolysis due to autoimmune hemolytic Anemic, transfusion reaction, liver disease, etc.

Question 10

Spherocytes

Answer 10

Hereditary spherocytosis or hemolytic anemia (extravascular)

Question 11

Positive osmotic fragility test

Answer 11

Hereditary spherocytosis

Question 12

Positive tube solubility test (sodium dithionite or sodium bisulfite)

Answer 12

Sickle cell

Question 13

Bar shaped crystals in red cells

Answer 13

Hemoglobin C for SC disease

Question 14

Low hemoglobin A, high hemoglobin A2

Answer 14

Beta thalassemia minor

Question 15

Cooley’s anemia, lifelong transfusions

Answer 15

Beta thalassemia major

Question 16

Hemoglobin H disease, hemoglobin BART in newborn

Answer 16

Alpha thalassemia

Question 17

Hi WBC count, shift to left (bands and meta myelocytes, all else is normal

Answer 17

Bacterial infection

Question 18

Normal or low WBC count, lymphocytosis

Answer 18

Viral infection

Question 19

Hi WBC count, lymphocytosis, small lymphocytosis, many smudge cells

Answer 19

Chronic lymphocytic leukemia

Question 20

Variant reactive atypical lymphatic

Answer 20

Infectious mono or other virus

Question 21

Dhole bodies in all wbc

Answer 21

May hegglin

Question 22

Toxic granulation

Answer 22

Infection or inflammation

Question 23

Crumpled “tissue paper” cell

Answer 23

Gaucherie disease

Question 24

Bubble-like cell

Answer 24

Nieman-pick disease

Question 25

Low lap score (20 or less)

Answer 25

Chronic myelogenous leukemia (cml)

Question 26

Philadelphia chromosome

Answer 26

Chronic myelogenous leukemia (cml)

Question 27

WBC greater than 300,000

Answer 27

Chronic myelogenous leukemia (cml)

Question 28

Auer rods

Answer 28

Acute myelogenous leukemia

Question 29

Normal or elevated wbc, blast cells, lymphocytosis

Answer 29

Acute lymphoblastic leukemia

Question 30

Tartaric acid (tartrate) resistant cells

Answer 30

Hairy cell leukemia

Question 31

Monoclonal gammopathy with bone lesions, bench jones proteins

Answer 31

Multiple myeloma

Question 32

Plasma cells in circulation

Answer 32

Multiple myeloma or plasma cell leukemia

Question 33

Positive esterase stain

Answer 33

Monocytic leukemia

Question 34

Myeloperoxidase, Sudan black B, periodic acid schiff positive stains

Answer 34

Myelogenous leukemia of some kind but not lymphotic

Question 35

Hemoglobin greater than 18 mg/dL or with normal PO2 levels

Answer 35

Polycythemia vera

Question 36

Platelet count greater than 600,000

Answer 36

Essential thrombocytothemia

Question 37

Fibroblasts in marrow

Answer 37

Chronic idiopathic myelofibrosis (also called agnogenic myeloid metaplasia)

Question 38

Chromosome translocation 9,22

Answer 38

Cml (Philadelphia chromosome)

Question 39

Low to normal WBC count, myleblast and circulation with high K+ and uric acid

Answer 39

Acute myelogenous leukemia

Question 40

Promyelocytes with auer rods, disseminated intravascular coagulation

Answer 40

Acute promyelocytic leukemia (release of granules causes DIC)

Question 41

Small "cleaved nucleus" lymphocytes

Answer 41

Lymphomas or whooping cough

Question 42

Small cleaved nucleus lymphocytes with skin involvement

Answer 42

Mycosis fungoides or sezary syndrome

Question 43

Reed Sternberg cells (owl eyes)

Answer 43

Hodgkin lymphoma

Question 44

Monoclonal gammopathy, no bone lesions

Answer 44

Waldenstrom's macroglobulinemia

Question 45

Hemoglobin and hematocrit do not match, low RBC, high HCB, high MCHC

Answer 45

Cold agglutinin

Question 46

Lymphocytes with many vacuoles

Answer 46

Burkitt's lymphoma

Question 47

No hemoglobin a, increased hemoglobin F

Answer 47

Sickle cell

Question 48

No hemoglobin a, increased hemoglobin A2

Answer 48

Beta Thalassemia

Question 49

Burkitt's lymphoma

Answer 49

Epstein-Barr virus