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Flashcards in Hematology / Oncology Deck (35)
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1

4 causes of Microcytic Anemia

TICS

Thalassemia
Iron Deficiency
Anemia of Chronic Disease
Sideroblastic Anemia

2

Elderly man with hypochromic, microcytic anemia is asymptomatic. Diagnostic Test?

Fecal Occult blood test and sigmoidoscopy

Suspect Colorectal cancer

3

Precipitants of hemolytic crisis in pt with G6PD deficiency

Sulfonamides
Antimalarial drugs
Fava Beans

4

Most common inherited cause of hypercoagulability

Factor V leiden Mutation

5

Most common inherited bleeding disorder

Von Willebrand's Disease

6

Most common inherited hemolytic anemia

Hereditary Spherocytosis

7

Pure RBC aplasia

Diamond-Blackfan Anemia

8

Anemia associated with abscent radii and thumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly and pancytopenia

Fanconi's Anemia

9

Medications and Viruses that lead to aplastic anemia

Chloramphenicol
Sulfonamides
Radiation
HIV
Chemo Agents
Hepatitis
Parvovirus B19
EBV

10

Distinguish Polycthemia Vera from 2 Plycythemia

Both have increase Hematocrit and RBC mass

Polycythemia Vera should have NORMAL 02 saturation and low erythropoietin levels

11

Thrombotic Thrombocytopenic Purpura (TTP) pentad?

FAT RN

Fever
Anemia
Thrombocytopenia
Renal Dysfunction
Neurologic Abnormalities

12

HUS Triad

Anemia
Thrombocytopenia
Acute renal failure

13

Treatment for TTP?

Emergent Large Volume plasmapheresis
Corticosteroids
Anti-Platelet drugs

14

Tx for Idiopathic Thrombocytopenic Purpura (ITP) in children

Usually resolves spontaneously

May require:
IVID and/or Steroids

15

Which of the following are increased in DIC:

Fibrin Split products
D- Dimer
Fibrinogen
Platelets
Hematocrit

Fibrin split products increase
D-dimers increase

Platelets Decrease
Fibrinogen Decrease
Hematocrit Decrease

16

8 y/o presents with hemarthrosis and increase PTT with normal PT and bleeding time. Diagnosis? Tx?

Hemophilia A or B; consider desmopression, or factor VIII or IX Supplements

17

14 y/o girl presents with prolonged bleeding after dental surgery and with menses, normal PT, normal or increase PTT, and increase bleeding time. Diagnosis? Tx?

Von williebrand's disease; treat with desmopressiin, FFP or Cryoprecipitate

18

60 y/o AA man presents with bone pain. Workup for multiple myeloma might reveal?

Monoclonal gammopathy
Bence Jones proteinuria
Punched out lesions on Xray of skill and long bones

19

Reed-Sternberg Cells

Hodgkin's Lymphoma

20

10 y/o boy presents with fever, weight loss, and night sweats. Exam shows anterior mediastinal mass. Suspected diagnosis?

Non-Hodgkin's Lymphoma

21

Microcytic Anemia with decrease serum iron, decrease total iron-binding capacity (TIBC) and normal or increase ferritin

Anemia of Chronic Disease

22

Microcytic Anemia with decrease serum iron, decrease ferritin and increase TIBC

Iron Deficiency Anemia

23

80 y/o man presents with fatigue, lymphadenopathy, splenomegaly, and isolated lymphocytosis. Suspected diagnosis

Chronic Lymphocytic Leukemia (CLL)

24

The Lymphoma equivalent of CLL

Small Lymphocytic Lymphoma

25

Late, Life-threatening complicatoin fo chronic myelogenous leukemia (CML)

Blast Crisis (Fever, Bone Pain, Splenomegaly, Pancytopenia)

26

Auer rods on blood smear

Acute myelogenous leukemia (AML)

27

AML Subtype associated with DIC

M3

28

Electrolyte changes in Tumor lysis syndrome

Decrease
- Ca

Increase
- K
- Phosphate
- Uric Acid

29

Treatment for AML M3

Retinoic Acid

30

50 year old man presents with early satiety, splenomegaly, and bleeding. Cytogenetics show t(9,22). Diagnosis?

CML

31

Heinz Body

Intracellular inclusions seen in thalassemia

G6PD
Post-Splenectomy

32

AR disorder with a defect in the GP IIB / IIIa platelet receptor and decrease platelet aggregation

Glanzmann's Thrombasthenia

33

Virus associated with aplastic anemia in pt with sickle cell anemia

Parvovirus B19

34

25 year old AA man with sickle cell anemia has sudden onset of bone pain. Pain management for crisis

02
Analgesia
Hydration
Transfusion

NEED TO TO MORPHINE

35

Significant cause of morbidity in thalassemia pt. Treatment?

Iron Overload

use Deferoxamine