Flashcards in Hematology / Oncology Deck (35)
4 causes of Microcytic Anemia
Anemia of Chronic Disease
Elderly man with hypochromic, microcytic anemia is asymptomatic. Diagnostic Test?
Fecal Occult blood test and sigmoidoscopy
Suspect Colorectal cancer
Precipitants of hemolytic crisis in pt with G6PD deficiency
Most common inherited cause of hypercoagulability
Factor V leiden Mutation
Most common inherited bleeding disorder
Von Willebrand's Disease
Most common inherited hemolytic anemia
Pure RBC aplasia
Anemia associated with abscent radii and thumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly and pancytopenia
Medications and Viruses that lead to aplastic anemia
Distinguish Polycthemia Vera from 2 Plycythemia
Both have increase Hematocrit and RBC mass
Polycythemia Vera should have NORMAL 02 saturation and low erythropoietin levels
Thrombotic Thrombocytopenic Purpura (TTP) pentad?
Acute renal failure
Treatment for TTP?
Emergent Large Volume plasmapheresis
Tx for Idiopathic Thrombocytopenic Purpura (ITP) in children
Usually resolves spontaneously
IVID and/or Steroids
Which of the following are increased in DIC:
Fibrin Split products
Fibrin split products increase
8 y/o presents with hemarthrosis and increase PTT with normal PT and bleeding time. Diagnosis? Tx?
Hemophilia A or B; consider desmopression, or factor VIII or IX Supplements
14 y/o girl presents with prolonged bleeding after dental surgery and with menses, normal PT, normal or increase PTT, and increase bleeding time. Diagnosis? Tx?
Von williebrand's disease; treat with desmopressiin, FFP or Cryoprecipitate
60 y/o AA man presents with bone pain. Workup for multiple myeloma might reveal?
Bence Jones proteinuria
Punched out lesions on Xray of skill and long bones
10 y/o boy presents with fever, weight loss, and night sweats. Exam shows anterior mediastinal mass. Suspected diagnosis?
Microcytic Anemia with decrease serum iron, decrease total iron-binding capacity (TIBC) and normal or increase ferritin
Anemia of Chronic Disease
Microcytic Anemia with decrease serum iron, decrease ferritin and increase TIBC
Iron Deficiency Anemia
80 y/o man presents with fatigue, lymphadenopathy, splenomegaly, and isolated lymphocytosis. Suspected diagnosis
Chronic Lymphocytic Leukemia (CLL)
The Lymphoma equivalent of CLL
Small Lymphocytic Lymphoma
Late, Life-threatening complicatoin fo chronic myelogenous leukemia (CML)
Blast Crisis (Fever, Bone Pain, Splenomegaly, Pancytopenia)
Auer rods on blood smear
Acute myelogenous leukemia (AML)
AML Subtype associated with DIC
Electrolyte changes in Tumor lysis syndrome
- Uric Acid
Treatment for AML M3
50 year old man presents with early satiety, splenomegaly, and bleeding. Cytogenetics show t(9,22). Diagnosis?
Intracellular inclusions seen in thalassemia
AR disorder with a defect in the GP IIB / IIIa platelet receptor and decrease platelet aggregation
Virus associated with aplastic anemia in pt with sickle cell anemia
25 year old AA man with sickle cell anemia has sudden onset of bone pain. Pain management for crisis
NEED TO TO MORPHINE