Hematopoiesis 1 and 2- Blood Flashcards Preview

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Flashcards in Hematopoiesis 1 and 2- Blood Deck (108)
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1

Define Hematopoiesis

The process of blood cell development

2

Hematopoietic Tissues (fetus, baby, adult)

Fetus---> Liver (primary), thymus, lymph nodes, and spleen. Baby --> entire marrow Adults -->Red Bone Marrow (of the humerus, femur, pelvis, skull, vertebrae and ribs)

3

What are the different formed elements?

RBCs, leukocytes, platelets

4

Blood volume is made up of:

RBCs: 41-53% in males 36-46% in females Leukocytes: <1% Plasma: 49-64%

5

Describe the characteristics of plasma

Plasma: 90% water 7% protein 0.9% inorganic ions the rest is nutrients, hormones, blood gases, etc.

6

Name major plasma proteins

albumin, globulins, fibrinogen and prothrombin

7

Define the term serum

The fluid portion of the blood obtained after the removal fibrin clot and blood cells.

8

What is the difference between plasma and serum?

serum does not contain clotting factors or platelets

9

Erythrocytes

Are mature RBCs

10

Macrocyte

Are large erythrocytes, larger than 9 mcm. Seen in cases of low folic acid.

11

Microcyte

A small, less than 6mcm, nonnucleated RBC. Seen in cases of low iron.

12

Reticulocyte

A young RBC; Usually about 1-2% of your RBCs; stain blue due to residual ribosomal RNA.

13

What is the concentration of RBC difference in males vs. females

males = 4.5-5.9x10^6 cells per microliter females = 4-5.2 x10^6 cells per microliter

14

What is the life span of a RBC?

120 days

15

What is the function of a RBC?

transport O2 through your body and to help remove CO2 from your body.

16

What are the two major types of leukocytes?

Granulocytes (polymorphonuclear) & Agranulocytes (mononuclear)

17

What are the different types of granulocytes?

Neutrophils, Esinophils, Basophils

18

Types of Agranulocytes?

Lymphocytes, Monocytes, Thombocytes (platelets)

19

what is the most abundant leukocute?

neutrophil

20

Characteristics of neutrophil

2x as big as RBC nuclei: 2-5 (usually 3 linked by chromatin) life span: SHORT (6-7 hrs in blood. 1-4 days in connective tissue)

21

Why can neutrophils survive in poorly oxygenated tissue?

Few mitochondria active glycolysis allows cell survival

22

Which leukocyte is the first leukocytes to extravasate in response to infection or injury

neutrophil

23

Leukocyte associated with allergic reactions and parasitic infections?

Eosinophils

24

Characteristics of eosinophil

same size as neutrophils nuclei: bilobed/trilobed; life span: 8-12 hours in blood, 8-12 days in tissue

25

Normal tissues eosinophils found in:

connective tissues underlying epitherlia of bronchi GI tract uterus vagina.

26

Least common leukocyte

basophils

27

Characteristics of basophils

IR lobed nucleus life span: 10-15 days in blood, few hours-days in tissues

28

Function of basophils

basophils bind IgE antibodies to acquire specificity for allergens. May serve as an antigen-presenting cell

29

most abundant agranulocyte

lymphocyte

30

type types of lymphocytes

T cells B cells NK cells