Hematopoiesis Flashcards
(11 cards)
What are the key regulating factors for Erythropoiesis?
- Erythropoietin
- GM-CSF
What is the meaning for GM-CSF?
Granulocyte Macrophage-Colony Stimulating factor
How many days does it take for Burst forming unit (BFU) to become a mature RBC?
18-21 days
Enumerate the Erythropoietic cells from Immature to Mature
Pronormoblast
Basophilic Normoblast
Polychromatic Normoblast
Orthochromic Normoblast
Polychromatic Erythrocyte
Erythrocyte
Enumerate the other names of the Erythropoietic cells from immature to mature
Rubriblast
Prorubricyte
Rubricyte
Metarubricyte
Reticulocyte
Erythrocyte
Identify:
NC Ratio: 1:2
Cytoplasm: abundant Hgb and fewer polyribosomes
Pyknotic nucleus
Last nucleated phase and strictly confined in the bone marrow
Orthochromic Normoblast (Metarubricyte)
Identify:
Nucleus: none
Cytoplasm: pink to slight pinkish gray as a result of retention of RNA
First stage released to peripheral circulation
Stays in circulation for 1-2 days
Polychromatic Erythrocyte (Reticulocyte)
Identify:
Nucleus: occupies about half of the cell area
Cytoplasm: blue gray to pink gray
NC Ratio: 4:1
Evident Hgb
Last stage capable of mitosis
Polychromatic Normoblast (Rubricyte)
Identify:
NC Ratio: 8:1
Nucleus: uniform chromatin pattern with prominent nuclear membrane; one or more nucleoli present
Cytoplasm: heterogenous quality with basophilia. No granules.
Globin production begins
Pronormoblast (Rubriblast)
Identify:
NC Ratio: 6:1
Nucleus: centrally located with coarser chromatin pattern
Cytoplasm: intensely basophilic
Hgb production begins
Basophilic Normoblast (Prorubricyte)
Identify:
Nucleus: none
Cytoplasm: pink to reddish pink
Erythrocyte
