Hemoglobin

Question 1

1 Hemoglobin is equal to how many of the ff:
Globin
Heme
Iron
Pyrole rings

Answer 1

4 Globin
4 Heme
4 Iron
16 Pyrole rings

Question 2

State or Iron in Heme synthesis

Answer 2

Ferrous state (Fe2+)

Question 3

Final product in hemoglobin synthesis

Answer 3

Protoporphyrin

Question 4

Enzyme responsible for the insertion of Iron

Answer 4

Ferrochelatase

Question 5

1 gene each for production of epsilon, beta, gamma, and delta chains

Answer 5

Chromosome 11

Question 6

3 genes for the production of alpha (2) and beta (1) chains

Answer 6

Chromosome 16

Question 7

Number of amino acids in Alpha chains

Answer 7

141

Question 8

Number of amino acids in Beta chains

Answer 8

146

Question 9

Parts of the cell involved in Heme synthesis

Answer 9

Mitochondria
Cytoplasm or Cytosol

Question 10

Part/s of the cell involved in Globin synthesis

Answer 10

Ribosomes

Question 11

Gower 1 structure

Answer 11

2 zeta, 2 epsilon

Question 12

Gower 2 structure

Answer 12

2 alpha, 2 epsilon

Question 13

Portland Structure

Answer 13

2 zeta, 2 gamma

Question 14

Embryonic Hemoglobin

Answer 14

Gower 1
Gower 2
Portland

Question 15

Hemoglobin A structure

Answer 15

2 alpha, 2 beta

Question 16

Hemoglobin A2 structure

Answer 16

2 alpha, 2 delta

Question 17

Hemoglobin F structure

Answer 17

2 alpha, 2 gamma

Question 18

Adult Hemoglobin

Answer 18

Hemoglobin A
Hemoglobin A2
Hemoglobin F

Question 19

Found in 95-98% adults and 10-40% newborn

Answer 19

Hemoglobin A

Question 20

Found in 3-5% adults and <2% newborn

Answer 20

Hemoglobin A2

Question 21

Found in 2% adults and >60% newborns

Answer 21

Hemoglobin F

Question 22

Affinity of Oxygen is 200 times higher than normal

Answer 22

Carboxyhemoglobin

Question 23

Color of blood when Carboxyhemoglobin is present

Answer 23

Cherry red

Question 24

Iron in Ferric state (Fe3+). Individuals are cyanotic

Answer 24

Methemoglobin

Question 25

Color of blood when Methemoglobin is present

Answer 25

Brown

Question 26

Hgb present in individuals with an inherited condition of Methemoglobin

Answer 26

Hgb M

Question 27

Toxic to humans; affinity to oxygen is 100 times more than normal; irreversible and not measured in the cyanmethemoglobin method

Answer 27

Sulfhemoglobin

Question 28

Color of blood when Sulfhemoglobin is present

Answer 28

Mauve Lavender

Question 29

Color of Sulfhemoglobin pigment

Answer 29

Green