RBC Inclusions And Their Compositions

Question 1

State inclusion composition and assoc. diseases/conditions
RBC inclusion:
Fine Basophilic Stippling

Answer 1

Composition: RNA
Hemolytic anemia
After tx of iron, vit. B12, or folate deficiency

Question 2

State inclusion composition and assoc. diseases/conditions
RBC inclusion:
Coarse Basophilic stippling

Answer 2

Composition: Precipitated RNA
Lead poisoning

Question 3

State inclusion composition and assoc. diseases/conditions
RBC inclusion:
Howell-Jolly Body

Answer 3

Composition: DNA (nuclear fragment)
Hyposplenism
Post splenectomy

Question 4

State inclusion composition and assoc. diseases/conditions
RBC inclusion:
Heinz body

Answer 4

Composition: denatured hgb
G6PD deficiency
Unstable hemoglobins
Oxidant drugs/chemicals

Question 5

State inclusion composition and assoc. diseases/conditions
RBC inclusion:
Pappenheimer bodies

Answer 5

Composition: Iron
Sideroblastic anemia

Question 6

State inclusion composition and assoc. diseases/conditions
RBC inclusion:
Cabot ring

Answer 6

Composition: remnant of mitotic spindle
Megaloblastic anemia
Myelodysplastic syndromes

Question 7

State inclusion composition and assoc. diseases/conditions
RBC inclusion:
Hgb H

Answer 7

Composition: precipitate of B-globin chains of Hgb
Hgb H disease