hematopoietic system

Question 1

in hematopoietic system, what are the changes that can happen in a normal maturation of cell?

Answer 1

changes in size, nucleus, cytoplasm, chromatin, and granules

Question 2

what is under the “Cytoplasmic changes”
provide the events under this one

Answer 2

there will be a loss of basophilia

A. loss of basophilia

Question 3

The cytoplasm of an immature cell is usually blue
or basophilic due to ___ content.

Answer 3

RNA

Question 4

Immature cells has ____ due to RNA

Answer 4

intense, dark color

Question 5

The more mature the cell, the ___because of the less RNA

Answer 5

less basophilic

Question 6

what is the purpose of red or acidic dye?

Answer 6

colors the acidophilic or eosinophilic granules

Question 7

purpose of the blue (basic) dye

Answer 7

colors the basophilic granules

Question 8

the use of basic and acidic dye

Answer 8

for Neutrophilic granules

Question 9

which is a special feature of
the maturation of erythrocytes

Answer 9

elaboration of hemoglobin

Question 10

do immature rbc has hemoglobin? what about nucleus?

Answer 10

immature rbc has no hemoglobin but has nucleus. Once they matured, they will lose the nucleus but will be able to contain hemoglobin

Question 11

how many stages are there for rbc to mature?

Answer 11

6 stages

Question 12

the process in which the nucleus of the matured rbcs are eliminated

Answer 12

nucleolysis or extrusion

Question 13

what are the 6 series of maturation of the rbc

Answer 13

2nd- start the synthesis of hgb
o 3rd- starts the synthesis of hgb
o 4th- stop the hgb synthesis
o 5th- reticulocytes
o 6th- matured erythrocytes

Question 14

Nuclear changes - what is the structure and chemistry

Answer 14

immature cells - round or oval
nuclear chromatin is very delicate and fine linear

Question 15

a chromatin for immature cells - delicate fine and linear is called

Answer 15

euchromatin

Question 16

what is the color of the euchromatin

Answer 16

pale blue - uncondensed

Question 17

As the cells matures chromatin strands
increasingly
coarse
and clumped
the euchromatin is now called as

Answer 17

heterochromatin

Question 18

as the cell mature, the chromatin before denser and has a color of

Answer 18

darker color

Question 19

if the shape of the cell change, do nucleus will change as well?

Answer 19

yes ofcors

Question 20

the older the cell the more segments or lobes that
nucleus has

true or false

Answer 20

true

Question 21

a neutrophil that has lobes mor than 5

Answer 21

hypersegmented neutrophils

Question 22

hypersegmented neutrophils is common in

Answer 22

megaloblastic anemia

Question 23

one of the feature or the hallmark of this disease- hypersegmented neutrophil

Answer 23

megaloblastic anemia

Question 24

reduction in cell size

It is a feature of all cells except in the

Answer 24

megakaryocytic series

Question 25

are matured cell supposed to be smaller than the immatured?

Answer 25

yes, they are generally supposed to be smaller than the immature cells

Question 26

what are the 4 things to remember in normal maturation?

Answer 26

cytoplasmic changes cytoplasmic granules nuclear changes reduction in cell size

Question 27

what are the 4 things to remember in abnormal maturation (asynchronistic)

Answer 27

abnormal cytoplasmic Differentiation Abnormal nuclear maturation Abnormal size

Question 28

In erythrocytes, this is characterized by persistent basophilia and late hemoglobinization

Answer 28

abnormal cytoplasmic Differentiation

Question 29

__ may be found in the cytoplasm of both erythrocytes and leukocytes, especially in the granulocytes

Answer 29

abnormal cytoplasmic inclusion

Question 30

INCLUSION BODIES ARE NOT SUPPOSED TO BE FOUND IN RBC AND BC TRUE OR FALSE?

Answer 30

TRUE

Question 31

3 EXAMPLE OF INCLUSION BODIES

Answer 31

INCLUSION BODIES: -HOWELL JOLLY -PAPPENHEIMER BODIES -HEINZ BODIES

Question 32

what is the cause of the hyposegmentation?

Answer 32

there's a problem with the lamin B

Question 33

which part of abnormal maturation is this leukemia the other severe disturbances, two nuclei may be present: one will be diploid and the other may be polyphoid

Answer 33

abnormal nuclear maturation

Question 34

in abnormal nuclear maturation, the ___ nucleus takes a longer time to mature than its cytoplasm

Answer 34

megalocytes

Question 35

which part of the abnormal maturation this happen abnormally large cells are frequently seen in benign or malignant proliferation

Answer 35

Abnormal size

Question 36

in abnormal maturation, the megalobast appears larger than the normal mature rbc true or false

Answer 36

true

Question 37

what are the 3types of human stem cell

Answer 37

Totipotential Stem cells Pluripotential Stem cells Multipotential Stem cells

Question 38

This type of stem cell is Present in the first few hours after an ovum is fertilized

Answer 38

Totipotential Stem cells

Question 39

a type of stem cell that is the Most versatile type of stem cell, can develop into any human cell type, including development from embryo into fetus

Answer 39

totipotential stem cell

Question 40

this type of stem cell is present in several days after fertilization

Answer 40

pluripotential stem cell

Question 41

this type of stem cell It can develop into any cell type except, they cannot develop into a fetus

Answer 41

pluripotential stem cell

Question 42

a type of stem cell that can't develop into a fetus

Answer 42

pluripotential stem cell

Question 43

this type of stem cell Derived from pluripotent stem cells

Answer 43

Multipotential Stem cell

Question 44

this type of stem cell is Found in adults, but limited to specific types of cells to forms tissues.

Answer 44

multipotential stem cell

Question 45

blast cell are can only be found in

Answer 45

bone marrow

Question 46

matured cells are all seen and found in

Answer 46

peripheral secretion

Question 47

how many days can retics stay in blood and bone marrow?

Answer 47

retics can stay in blood - 1 day bone marrow - 2 days

Question 48

first recognizable erythroid precursor

Answer 48

rubliblast

Question 49

what is the 3 nomenclature of erythrocytes

Answer 49

rubliblast, pronormoblast, ?

Question 50

in the erythrocyte lineage, what follows rubriblast?

Answer 50

o Rubriblast o Prorubricyte o Rubricyte o Metarubricyte o Reticulocyte o Erythrocyte

Question 51

what is the first recognizable cell in granulophoresis

Answer 51

myeloblast

Question 52

characteristic of a cytoplasm of a blast cell

Answer 52

very dark blue and small in amount in comparison to the size of the nucleus. No granular is present.

Question 53

characteristic of a nucleus of a blast cell

Answer 53

large in size as compared to the size of cytoplasm. Chromatin which is reddish purple and indicates predominance of DNA.

Question 54

5 process inckded on the Hematopoietic system

Answer 54

 Erythropoiesis  Granulopoiesis  Monopoiesis  Lymphoiesis  Megakaryopoiesis

Question 55

Is a process by which erythroid precursor cells differentiates to become mature.

Answer 55

Erythropoiesis

Question 56

The primary regulator of the erythropoiesis is

Answer 56

Erythropoietin

Question 57

where can we found the EPO?

Answer 57

kidney and a little on a liver

Question 58

what is a first recognizable precursor in erythropoiesis

Answer 58

Pronormoblast (Rubriblast)

Question 59

ratio of the nucleus to the cytplasm of the rubriblast

Answer 59

8:1

Question 60

location of the pronormoblast

Answer 60

bone marrow in healthy states

Question 61

Cellular Activity. The pronormoblast begins to ___ necessary for hemoglobin production

Answer 61

accumulate the components

Question 62

when do Globin production begins. And This stage lasts slightly more than 24 Hours

Answer 62

In the pronormoblast

Question 63

how many products do pronormoblast produced?

Answer 63

2 prorubricyte

Question 64

the 2d stage of maturation of rythrocyte

Answer 64

Basophilic Normoblast(Prorubricyte)

Question 65

ratio of nucleus and cytoplasm in stage Basophilic Normoblast(Prorubricyte)

Answer 65

6:1

Question 66

how many products do Basophilic Normoblast(Prorubricyte) produced?

Answer 66

4 rubricyte

Question 67

diference of rubliblast and proribrucyte

Answer 67

 diff: coarse chromatin  absence of nucleoli

Question 68

first stage of hemoglobin synthesis

Answer 68

prorubricytes or basophilic normoblast

Question 69

3rd stage of rbc maturation

Answer 69

Polychromatic (Rubricyte) (Polychromatophilic) Normoblast

Question 70

The chromatin pattern varies during this stage of development, showing some openness early in the stage but becoming condensed by the end.

Answer 70

Polychromatic (Rubricyte) (Polychromatophilic) Normoblast

Question 71

the last stage of undergoing mitosis for rbc

Answer 71

Polychromatic (Polychromatophilic) Normoblast (Rubricyte)

Question 72

whatis the product of the 3rd stage, rubricyte?

Answer 72

2 metarubricyte

Question 73

rubricyte is always compared to what cell?

Answer 73

lymphocyte

Question 74

nucleus and cytoplasm of rubricyte is

Answer 74

checked board and muddy/colored gray

Question 75

First stage in which cytoplasm becames PINK blue to increase hgb componen

Answer 75

rubricyte

Question 76

how many hours do rabricyte last

Answer 76

30 hrs

Question 77

Metarubricyte is also called as

Answer 77

Orthochromic Normoblast

Question 78

Orthochromic Normoblast (Metarubricyte) aka

Answer 78

late normoblasts

Question 79

this is where the nucleus condensed, 1:2, the cytoplasm is salmon-pink already No mitosis will take place

Answer 79

Orthochromic Normoblast (Metarubricyte)/ late normoblast

Question 80

No nucleus but has mitochondria and ribosomes  Last stage to synthesize hemoglobin. Last stage in bone marrow before release to the blood

Answer 80

reticulocyte

Question 81

stain used for reticulocyte

Answer 81

supravital stain

Question 82

the last stage of erythropoiesis

Answer 82

Erythrocyte

Question 83

abormal shaped rbc that has no central pallor is called

Answer 83

spherocytes

Question 84

types of myeloblast

Answer 84

Type I- nucleus is open o Type II- presence of primary granu type III - mas matingkad na kulay

Question 85

granulophoresis stages

Answer 85

myeloblast promyelocyte myelocyte metamyelocyte non-segmented granulocyte segmented granulocyte

Question 86

there's a presence of HOF or paranucleear halo

Answer 86

promyelocyte

Question 87

only seen in promyelocyte and can appear onlyifthe promyelocyte is healthy

Answer 87

paranuclear halo

Question 88

first recognizable formation of granules

Answer 88

promyelocyte

Question 89

final stage in which cell division (mitosis) occurs

Answer 89

neutrophil myelocyte

Question 90

final stage in which cell division (mitosis) occurs is also called as the

Answer 90

dawn of neutrophilia

Question 91

a stage wherethe seconfary specific granules are created

Answer 91

myelocyte

Question 92

metamyelocytes is also called as

Answer 92

Aka Juvenile cells

Question 93

Final stage of nuclei indentation  Tertiary granules- gelatinase

Answer 93

metamyelocyte