Hematopoietic System

Question 0

Plasma membrane’s shape is dependent on what?

Answer 0

ATP

Question 1

Dominant organelles at mature RBC

Answer 1

Mitochondria

Question 2

RBC’s size indicates __.

Answer 2

Rate of production and destruction

Question 3

True or False: RBC can change shape to fit thru small BVs

Answer 3

True

Question 4

The following biomolecules are needed in RBC prod except
A.vit B12
B.iron
C.folic acid
D.fructose

Answer 4

D.fructose

Question 5

What hormone is needed for RBC prod and where is it produced?

Answer 5

Erythropoietin, kidney

Question 6

Arrange sequence of hematopoietic organs: I.bone marrow, II.yolk sac, III.liver

Answer 6

II THEN III THEN I :)

Question 7

As we age, red bone marrow becomes filled with ___. This is called yellow marrow

A.carbohydrates
B.proteins
C.adipose
D.ice

Answer 7

C.adipose

Question 8

Absence of erythropoietin leads to ___ in committed erythropoietic cells

Answer 8

Apoptosis

Question 9

Sequencing
I.basophil erythroblast
II.reticulocyte
III.proerythroblast
IV.erythrocyte

Answer 9

III then I then II then IV

Question 10

Basophilic erythroblast contains ____(little, abundant) hemoglobin

Answer 10

Little

Question 11

Which does not directly cause increased erythropoietin production?
A.anemia
B.hypoxemia
C.renal artery stenosis
D.low hemoglobin
E.impaired oxygen loading
F.low WBC count

Answer 11

F.low WBC count

Question 12

Hemostasis can be directly achieved by the following mechanisms except:
A)vascular dilation
B)formation of platelet plug
C)formation of blood clot due to blood coagulation
D)growth of fibrous tissue into blood clot
E)blood filtration by kidneys

Answer 12

E)blood filtration by kidneys

Question 13

Procoagulant forces promotes the following except
A)platelet adhesion
B)fibrin clot formation
C)vascular dilation

Answer 13

C)vascular dilation

Question 14

Anticoagulant forces promote all except
A)vascular constriction
B)fibrinolysis
C)coagulation inhibition

Answer 14

A)vascular constriction

Question 15

The vessel wall is a major component of the human hemostatic system, true or false?

Answer 15

True

Question 16

The following may cause blood vessels to constrict as hemostatic response...except:
A.local myogenic spasm
B.nervous reflex
C.thromboxane A2
D.dengue virus

Answer 16

D.dengue virus

Question 17

This factor is primary mediator of platelet adhesion. Location:ECM of subendothelial wall and plasma

Answer 17

von Willebrand factor

Question 18

Platelets directly bid to subendothelial ___ to facilitate platelet adhesion

Answer 18

Collagen

Question 19

Platelet ___ complex: most abundant receptor on platelet surface. When active, it binds to fibrinogen & von Willebrand factor

Answer 19

Glycoprotein IIb/IIIa

Question 20

Platelet aggregation is enhanced by all except:
A.epinephrine
B.thrombin
C.adenosine diphosphate
D.serotonin
E.collagen
F.von Willebrand factor
G.fructose

Answer 20

G.fructose

Question 21

Additional platelets are recruited to site of injury, leading to formation of ___

Answer 21

Platelet thrombus

Question 22

When platelet plug is anchored, it is stabilized by ___

Answer 22

Fibrin mesh

Question 23

Fibrin clot formation has 3 basic steps. Arrange natin!
I. Fibrinogen conversion to fibrin
II. Prothrombin becomes thrombin
III. Prothrombin activator is formed

Answer 23

III THEN II THEN I :)

Question 24

Prothrombin activator converts prothrombin to thrombin in the presence of ___ ions

Answer 24

Calcium

Question 25

___ converts fibrinogen to fibrin

Answer 25

Thrombin

Question 26

T or F: plasma coagulation proteins normally circulate in their active forms

Answer 26

False. *inactive forms

Question 27

Extrinsic factor pathway is initiated by __

Answer 27

Material external to the blood

Question 28

Intrinsic factor initiated by __.

Answer 28

Blood coming in contact with exposed collagen at BV wall

Question 29

Coagulation is normally initiated through ___, which is composed mainly of phospholipids from membrane of damaged tissue + lipoprotein complex

Answer 29

Tissue factor/tissue thromboplastin

Question 30

____ pathway starts with release of tissue factor

Answer 30

Extrinsic

Question 31

Tissue factor combines with (A) and in the presence of (B) ions to form (C)

Answer 31

(A)factor VII (B)Calcium (C)Factor X

Question 32

Factor X combines with these to form prothrombin activator, except A. Factor V B.tissue phospholipids C. Collagen

Answer 32

C.collagen

Question 33

The ___ pathway is composed of Release of tissue factor Activation of factor X Formation of prothrombin activator

Answer 33

Extrinsic

Question 34

First step for intrinsic pathway

Answer 34

Factor XII activated,release of platelet phospholipids

Question 35

Factor XII is activated when it comes into contact with ___

Answer 35

Collagen

Question 36

In the 1st step of intrinsic pathway,platelets also release __

Answer 36

Platelet factor 3

Question 37

Second step, intrinsic pathway

Answer 37

Factor XI is activated

Question 38

Another name for Factor XI

Answer 38

Prekallikrein

Question 39

Factor XIIa activates Factor XI in the presence of high-molecular weight ____.

Answer 39

Kininogen

Question 40

. (3rd step, intrinsic pathway)

Answer 40

Factor XIa activates factor IX

Question 41

___ activates factor VII

Answer 41

Thrombin

Question 42

``` The following activate Factor X in the intrinsic pathway,except? A.factor IXa B.factor VIIIa C.platelet phospholipids D.factor IIa E.platelet factor 3 ```

Answer 42

D.factor IIa

Question 43

(Intrinsic pathway)Factor Xa combines with the ff except __ to form prothrombin activator. A. Tissue phospholipids B.collagen C.factor Va

Answer 43

B.Collagen

Question 44

Fibrinogen is also known as...

Answer 44

Factor I

Question 45

Prothrombin is also known as..

Answer 45

Factor II

Question 46

Tissue factor is also known as tissue thromboplastin &...

Answer 46

Factor III

Question 47

Calcium is also known as...

Answer 47

Factor IV

Question 48

Factor IX is also known as..

Answer 48

Christmas factor

Question 49

Common functions of prostacyclin, nitric oxide and ectoADPase/CD39

Answer 49

Inhibit platelet binding, secretion and aggregation

Question 50

``` All are anticoagulant factors produce by endothelial cells except A)prostaglandin B)antithrombin C)thrombomodulin D)heparan proteoglycans E)TF pathway inhibitor ```

Answer 50

A)prostaglandin

Question 51

``` The following activate fibrinolytic mechanisms except A.tissue plasminogen activator 1 B.urokinase C.annexin-2 D.plasminogen activator inhibitor E.hexokinase ```

Answer 51

E.hexokinase

Question 52

Neutralizes thrombin and other activated coagulation factors

Answer 52

Antithrombin

Question 53

Rate of antithrombin formation increasdd by ___

Answer 53

Heparin

Question 54

Plasma glycoprotein that becomes anticoagulant when activated by thrombin

Answer 54

Protein C

Question 55

Protein C activation (c/o thrombin) happens at___

Answer 55

Thrombomodulin

Question 56

How does Protein C become anticoagulant?

Answer 56

Cleaves and inactivates Factor V and VIII

Question 57

Protein C anticoagulant action accelerated by ____, which undergoes vitK dep posttranslational modification

Answer 57

Protein S

Question 58

regulates TF-induced extrinsic pathway of coagulation by inhibiting TF/VIIa/Xa complex

Answer 58

Tissue factor pathway inhibitor

Question 59

Major protease enzyme of fibrinolytic system

Answer 59

Plasmin

Question 60

Tissue type plasminogen activator (tPA) and ______ type plasminogen activator cleave -------- bond of plasminogen to generate plasmin

Answer 60

____:urokinase | -----:Arg560-Val561

Question 61

___-binding sites of plasmin permit it to bind to fibrin

Answer 61

Lysine

Question 62

Third step of fibrinolysis

Answer 62

Fibrin is cleaved by plasmin at diff sites ---> fibrin fragments

Question 63

Primary inhibitor of tPA and uPA in plasma

Answer 63

PAI1

Question 64

Main inhibitor of plasmin in human plasma, inactivates any nonfibrin clot-associated plasmin

Answer 64

Alpha-2 antiplasmin