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Question 1

what does an increased/decreased reticulocyte index tell us?

Answer 1

increased = high RBC destruction
decreased = low RBC production

Normal - 1-2%

Question 2

what are sx of anemia

Question 3

what is the w/u for anemia

Question 4

what are the microcytic anemias?

Question 5

how are thalassemia diagnosed? what are the different types?

Question 6

what is Plummer-Vinson syndrome?

Answer 6

dysphagia + esophageal webs + atrophic glossitis + Fe deficiency

Question 7

Lab findings for iron deficiency anemia

Question 8

what is on your ddx for iron deficiency anemia

Question 9

lab findings in anemia deficiency anemia

Question 10

sideroblastic anemia - who gets it, what will you see on labs?

Question 11

what type of anemia would you see in lead poisoning? lab findings?

Question 12

tx for anemia dt lead poisoning?

Question 13

ddx for normocytic anemia

Answer 13

1. anemia of chronic dz
2. blood loss
3. drug or viral induced suppression (chemo, hepatitis, EBV, HIV, parovirus)
4. Malignant infiltration of bone marrow (myeloma, lympphomas, leukemias, bone mets)

Question 14

ddx for macrocytic anemia

Question 15

B12 deficiency anemia - who gets it, how do they present, what would you see on labs?

Question 16

What does the Schilling test help you differentiate between?

Question 17

folate deficiency - who gets it, how do they present, lab findings

Question 18

ddx for hemolytic anemia

Question 19

classic labs for hemolytic anemia

Question 20

Coombs test - when is it positive vs negative

Question 21

hereditary spherocytosis

Question 22

what is the amino acid substitution seen in sickle cell?

Question 23

sickle cell presentation

Question 24

what is seen in peripheral smear for sickle cell

Question 25

common sickle cell complications

Question 26

general sickle cell dz managment

Question 27

heinz bodies and bite cells on peripheral smear indicates what?

Question 28

common oxidative stressors in G6PD?

Question 29

aplastic anemia - what is it, who gets it, how do they present and what do you do?

Question 30

define neutropenia vs agranulocytosis

Question 31

neutropenic fever

Question 32

what labs would you see in autoimmune hemolytic anemia? cold vs warm?

Question 33

pernicous anemia - why does it happen, how do you dx, how do you treat?

Question 34

compare presentation of primary vs secondary hemostasis problems

Question 35

what is the MC inherited bleeding disorder?

Question 36

von Willebrand dz - who gets it, how do they present, labs and tx?

Question 37

what clotting factor deficiency is seen in hemophilia A vs B vs C?

Question 38

what is does the aPTT/PT look like in hemophilia

Question 39

PTT vs PT/INR

Question 40

thrombotic conditions ddx who do we test?

Question 41

ITP - what is it, who gets it, how do they present, labs

Question 42

ITP - how do we treat

Question 43

what lab is ordered to r/o DIC?

Answer 43

fibrinogen

Question 44

what is the classic pentad seen in TTP?

Answer 44

1. severe thrombocytopenia 2. microangiopathic hemolytic anemia 3. fever 4. renal insufficiency 5. neurologic abnormalitis | *MUST have thrombocytopenia and anemia!!

Question 45

what lab findings indicates hereditary TTP

Question 46

TTP treatment

Question 47

what is the classic triad seen in HUS

Question 48

HUS

Question 49

DIC - who gets it, how do the present, lab findings

Question 50

DIC treatment

Question 51

polycythemia vera - how to they present, major/minor criteria, how do you treat?

Question 52

what mutation is commonly seen in polycythemia vera?

Answer 52

Jak-2 mutation

Question 53

secondary erythrocytosis - what causes it, how do they present?

Question 54

WBC differential - ddx for the -philias

Question 55

hemochromotosis - who gets it, how do they present, labs, tx

Question 56

immune vs non-immune mediated transfusion rxn

Question 57

Tx of transfusion rxn

Question 58

what is the most common leukemia in childhood?

Answer 58

ALL

Question 59

child presents with persistent fatigue, malaise, bone pain, night sweats, bleeding and easy bruising PE shows lymohadenopathy, pallor and petechiae labs show pancytopenia, smear with blasts, and bone marrow bx have blasts >20% what is the likely dx?

Answer 59

ALL

Question 60

AML - who gets it and how do they present

Question 61

Auer rods are seen on bone marrow bx, what is this assoc with?

Answer 61

AML

Question 62

CLL

Question 63

smudge cell

Question 64

when is tx indicated for CLL?

Question 65

CML

Question 66

what is the age distribution seen in hodgkin's lymphoma

Question 67

19 y/o male presents with painless lymphadenopathy, significant B symptoms reed sternberg cells are noted on labs

Question 68

describe the staging for hodgkins

Question 69

non-hodgkins

Question 70

describe the classic presentation of multiple myeloma

Question 71

labs for multiple myeloma

Question 72

myelodysplastic synddrome