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Flashcards in Heme/Onc SBSI Deck (117)
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1

complications of hemophilia

arthropathy, spontaneous intracerebral, renal, retroperitoneal, and GI hemorrhages

2

tx of severe hemophilia

immediate transfusion of missing factor or cryoprecipitate

3

initial test for hemophilia

mixing study, PTT corrects after mixing

4

what is prolonged in hemophilia?

PTT

5

what does cryoprecipitate consist of?

mainly Factor VIII and fibrinogen

6

tx of mild hemophilia

desmopressin, releases factor VIII from endothelial cells

7

MC inherited bleeding disorder?

von willebrand disease

8

child with prolonged or recurrent mucosal bleeding and bleeding after dental or sx (epistaxis or menorrhagia)

positive family hx

von willebrand disease

9

initial test for von willebrand disease

increased BT and increased PTT

PT and plts are normal

10

most accurate test for vWD

ristocetin cofactor assay of pt plasma

11

mild to moderate vWD tx

desmopressin

12

what will worsen vWD?

ASA, NSAIDs, plt function inhibitors

13

acute neutropenia, what bugs are more likely?

S. aureus, Pseudomonas, E. coli, proteus, and klebsiella

14

best initial test for neutropenia

CBC with smear

after looking at drugs they are on

15

if decreased platelets and anemia with neutropenia, what should you get

bone marrow biopsy and/or aspirate

16

neutropenic fever, tx?

emergency

broad spec abx, cefepime

tx suspected fungal as well

17

what can be given to shorten duration of neutropenia?

G-CSF

18

What cytokines overproduced can cause eosinophilia?

IL-3, IL-5, GM-CSF

or by chemokines

19

dx with eosinophilia starts with 

CBC with diff

20

CSF showing eosinophilia is suggestive of 

drug reaction or infxn with coccidio or helminth

21

hematuria with eosinophilia

schistosomiasis

22

tx of new onset cardiac findings, eosinophilia or drug rxn

steroids

23

transplantation between identical twins

syngenic transplantation

24

complication of allogenic bone marrow transplantation in which donated T cells attack host tissues, especially skin, liver, and GI tract

graft v host

25

skin changes, cholestatic liver dysfunction, obstructive lung disease, or GI problems after transplant

graft v host

26

transplantation, 5 days to 3 months, increase GGT, alk phos, LDH, BUN, or Cr

acute rejection

27

vascular thrombi or tissue ischemia after transplant

hyperacute rejection

28

young, white pt, <45 yo with personal and family hx of thrombosis

Factor V Leiden 

29

hyperhomocysteinemia

MTHFR gene mutation

30

test for factor V Leiden

activated protein C resistance test