Hemo exam 5 > Hemo exam 5 > Flashcards

Hemo exam 5 Flashcards

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1
Q

Order of Granulocyte production

A

PPSC, myeloblast, promyelocyte, myeloctye, metamyeloctye, band, mature

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2
Q

has primary granules that are not committed

A

promyelocyte

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3
Q

has seconday granules that are committed

A

myelocyte

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4
Q

stops dividing at

A

myelocyte

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5
Q

Mature granulocyte only found in

A

peripheral blood

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6
Q

only granulocyte we keep track of

A

mature granulocyte

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7
Q

Pool/compartments (6)

A

dividing, maturation, storage, circulating, marginating, tissue

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8
Q

dividing (proliferating) pool is in the

A

bone marrow

d

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9
Q

diving (proliferating) pool contains

A

myeloblasts, promyelocytes, myelocytes

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10
Q

maturation pool is located in

A

bone marrow

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11
Q

maturation pool contains

A

myelocytes, metamyelocytes, bands

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12
Q

storage pool is located in the

A

bone marrow

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13
Q

storage pool contains

A

few bands, mostly mature

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14
Q

defining cell of inflammation

A

band

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15
Q

dogs have how many days of back up supple of segs in storage pool

A

5 days

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16
Q

complete turn over of segs

A

2-2.5 days

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17
Q

half life of segs is

A

6 hours

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18
Q

segs are

A

bacterial phagocytes that destroy themselves

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19
Q

circulating pool is located

A

in the blood

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20
Q

stay in circulating pool for

A

6-8 hours

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21
Q

marginating pool located

A

in between endothelial cells to move to tissues

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22
Q

when segs move to tissues called

A

diapedesis

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23
Q

segs are in tissues when

A

they are needed

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24
Q

seg stimulus(2)

A

PG in cell wall, infx and non infx inflammation

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25
what release prostaglandins
cell damage
26
seg function (2)
primary bacterophage, inflammatory mediator
27
eos stimulus(2)
parasites with long tissue migration, allergic conditions
28
eos function
parasitocidal, anti allergy
29
how do dos kill parasite
spray granules on parasite for acid affect
30
eos granules include
antihistamine
31
basis are partners with
t-lymphs
32
baso stimulus
immediate hypersensitivity
33
baso function
anaphylaxis
34
baso granules contain
histamine and heparin
35
baso causes release of
eos
36
Only WBC to recirculate
lymphocytes
37
stimulus for production for lymphocyte is
antigen
38
function of lymphocyte
antibody production
39
order of maturation lymphocyte
resting memory cell, lymphoblast, prolymphocyte, lymphocyte
40
resting memory cell made in
lymphoid tissue (thymus) no PPSC
41
primary lymphocyte is
B lymphs
42
can you tell the difference between b lymphs and t lymphs
no
43
monocyte maturation starts in
bone marrow
44
stimulus for monocyte
same as seg
45
function of monocyte 2
clean up what segs left behind, become macrophage
46
monos stay in circulation for
2 hours
47
monos go to tissues to become
macrophage
48
order of maturation monocyte
PPSC, monoblast, promonocyte, monocyte
49
count immature segs
bands
50
if see meta write
back to meta
51
hypersegmented neutrophils are referred to as
right shift
52
hypersegmented neutrophils een on
40x
53
how many lobes must have to be considered hypersegmented
5 lobes
54
pyknosis means
cells are dead
55
see toxic neutrophils on
100x
56
toxic neutrophils indicate
sloppy maturation, demand, infection somewhere
57
write toxic neutrophil for
blue cytoplasm, dohle body, cytoplasmic vacuoles, azurophilic granules
58
azurophlic granules are
dark purple granules that should have gone away, 1* granules
59
dohle bodies are
blue inclusions irregular in shape
60
lymphoblast has
open chromatin, ,may have nucleolus
61
lymphocyte with cleft or bleb has
cleft in nucleus
62
50% or more lymphocytes have
cleft or bleb in nucleus
63
on note cleft or bleb when
moderate or marked
64
reactive cytoplasm of lymph
deeply basophilic cytoplasm +/- perinuclear halo
65
magnification to note reactive cytoplasm in a lymph
100x
66
see reactive lymph in
mammals, exotics in peripheral blood smears
67
granular cytoplasm in a lymph
see azurophilic dark purple staining granules in cytoplasm
68
a plasma cell is a
lymph with an eccentric nucleus, NC ratio low and very clear perinuclear halo
69
plasma cells seen in
peripheral blood smears of birds and reptiles
70
note plasma cell as
lymph
71
mott cell
lymph feel with russel bodies in the cytoplasm, looks constipated
72
mott cell seen in
birds
73
whats going on with mott cells
cell producing antibody but not releasing them
74
common to see nuclear changes in a monocyte?
no
75
cytoplasmic changes in monocytes are most commonly seen in
animals with IMHA, pathognomonic
76
hemosiderin cytoplasm of monocyte
iron deposits in cytoplasm, pathognomonic for IMHA
77
erythrophagocytosis
monocyte with RBC inside
78
percent neutrophils in dog/cat
55-85%
79
percent lymph in dog/cat
15-45%
80
percent mono/eos in dog/cat
0-5%
81
regenerative left shift is
leukocytosis with an increase in bands
82
degenerate left shift is
leukopenia with =/> 10% bands
83
right shift is
hypersegmentation
84
3 general causes of hypersegmentation
not making blood film right away, poodles macrocytosis, glucocorticoids
85
how do glucocorticoids cause hypersegmentation
causes a decrease in diapedesis
86
in leukogram look at
total WBC count then distribution
87
what influences WBC count the most
segs and lymphs
88
3 special leukograms called
neutrophilic leukocytosis
89
inflammation leukogram also known as
regenerative left shift
90
chemical mediator/stimulus of inflammatory leukogram
PG, bacterial products, infx&noninfx inflammation
91
inflammation leukogram distribution
Seg:i, bands:i, lymphs:n, monos:i, eos;n, bands;0
92
with inflammation leukogram always see
i in bands
93
stimulus of stress leukogram
glucocorticoids
94
distribution of stress leukogram
segs;i, bands;0, lymphs;d, monos;i, eos;d, baso;0
95
with stress always see
A decrease in lymphs, and eos
96
physiologic leukogram stimulus
epinephrine
97
physiological leukogram distribution
seg;i, bands;0, lymph;i, monos;i, eos;i, baso;i
98
physiological leukogram always see
increase in all including basos, no bands
Hemo exam 5
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