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Flashcards in Hemostasis Deck (18):
1

Thrombin --> fibinogen --> fibrin clot
For this to occur what must be present

Plasma membrane and calcium

2

Factors II, VII, IX, and X are dependent on what

Vitamin K

3

Aspirin interferes with PTL aggregation by blocking the formation of

Thomboxane A2

4

Coumanin (Warfarin) produces anticoagulant effects by interfering with the ability of ...

Vit K to serve as a co-factor in the synthesis of these coagulation factors (esp. Factor VII)

5

The overlap of the extrinsic and intrinsic pathway result in the common pathway. What steps are included in this step:

Activation of Factor X, the formation of Thrombin, and the conversion of Fibrinogen to fibrin

6

Key players in terminating coagulation

Antithrombin, Protein C, and Protein S

7

Heparin amplifies the effects of _______ a thousand fold

antithrombin

8

Protein C inactivates ________ and ______ to decrease the formation of thrombin

Factor V and Factor VIII

9

_______ is a co-factor required for the normal function of protein C

Protein S

10

The most important rxn in the fibrinolytic system is the formation of ______ from the plasma protein _______

1) plasmin
2) plasminogen

11

Lab test: Bleeding Time is measuring if what things are working?

Small wound so PLT plug alone should stop bleeding. Therefore measuring *PTL function and activity of VWF.
Normal bleeding time = <10 minutes

12

2 lab tests of primary hemostasis

Bleeding Time and PLT count

13

3 lab tests of secondary hemostasis

Prothrombin Time (PT), International Normalized Ratio (INR), and Partial Thromboplastin Time (PTT)

14

A procedure that measures the activity of the coagulation factors in the extrinsic and common pathways by measuring how long it takes plasma to clot in a test tube after tissue factor (rat brain) and Ca2+ has been added

Prothrombin Time (PT)
Normal range: 11-13 seconds

15

This lab procedure is used to evaluate the activity of coagulation factors in the intrinsic and common pathways by measuring how long it takes plasma to clot in a test tube after substances such as silicate particles (Georgia clay) have been added to the plasma

Partial Thromboplastin Time (PTT)
Normal range: 25-35 seconds

16

PT commonly used to monitor...

Cuminin (Warfarin)

17

PTT commonly used to monitor...

Heparin

18

Measures the function of the last step in the coagulation casacade --the conversion of fibrinogen to fibrin by thrombin

Thrombin Time (TT)