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Flashcards in Macrocytic Anemia Deck (12):
1

This group of anemias get their name from the presence of abnormally large RBC precursor cells in the bone marrow

Megaloblastic anemias

2

Underlying problem in megaloblastic anemia is deficiency of ....

vitamin B12 and/or folic acid (both of which are necessary for normal DNA synthesis by erythrocyte precursors in the bone marrow)

3

B12 deficiency interferes with ___________ of nerves so __________ symptoms can be seen

1) mylination
2) neurologic

4

Most common case of B12 deficiency

pernicious anemia

5

T/F: Lack of B12 in diet is a usual explanation for megaloblastic anemia

FALSE: B12 is stored in the liver for 3-6 years. Only strict vegetarians are at risk for dietary B12 deficiency

6

Most common underlying cause of folic acid deficiency in the US is

alcoholism

7

T/F: Folic acid deficiency does not produce neurological symptoms

True

8

Most reliable way to differentiate between the two major causes of megaloblastic anemia

Measuring serum levels of B12 and folate

9

B12 deficiency is associated with an elevation of both _____ and ______. Whereas, folate deficiency is associated with an elevated _____ but _____ is normal.

1) MMA (serum methymalonc)
2) HC (homocysteine)
3) HC
4) MMA

10

If diagnosis proves to be pernicious anemia, patients are treated with...

IM B12

11

Treatment of folic acid deficiency

1) Oral folic acid (1-5mg/day for 1-4 months)
2) Alcoholics should be advised to stop drinking

12

Other causes of macrocytosis (other than megaloblastic)

Hypothyrodism, liver disease, alcoholism, recent hemolysis, hematologic malignancies, some drugs (AZT, dilatin, methotrexate, azathoprine)