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Flashcards in Microcytic Anemia Deck (14):
1

The most common cause for iron deficiency in adults is _________ not _____

1) blood loss
2) dietary iron deficiency

2

Condition associated with development of abnormal, dilated, blood vessels within the wall of the bowel that bleed easily

Angiodysplasia

3

The earliest, and most sensitive, laboratory indicator of iron deficiency is a reduction in?

Serum ferritin

4

With a well established iron deficiency you will usually see a decrease in serum iron and an increase in...

TIBI (TIBC increases because of the body's attempt at increasing availability of iron by synthesizing more transferrin)

5

The “classic” picture of full blown______ is a microcytic, hypochromic anemia with decreased serum ferritin, low serum iron, increased TIBC, and reduced transferrin saturation.

Iron deficiency

6

Typical iron replacement therapy

Ferrous Sulfate 325 mg 3x per day

7

Inherited genetic disorders associated with defects in the synthesis of the globin subunits of hemoglobin

Thalassemia

8

Which have lower MCV counts: iron deficiency or thalassemias?

Thalassemias (MCV below 70 fl)

9

Anemia of chronic disease is caused by...

Chronic infections, inflammatory disease, and some malignancies

10

What is the mechanism for ACD

Defect in the ability of the body to deliver iron from storage sites to the bone marrow where it can be used for RBC production

11

Treatment of ACD

Correct underlying disease. Blood transfusion can be useful if serve. Some forms respond to erythropoietin. Iron therapy is NOT effective

12

Why does lead cause mycocytic anemia?

Lead interferes with the functioning of an enzyme that is necessary for the incorporation of iron into the heme molecule

13

Bluish speckled appearance on RBC associated with lead poisoning

Basophilic stippling

14

Can be inherited but most commonly caused by exposure to certain drugs or toxins

Sideroblastic anemia