Heparin (+LMWH) Flashcards
1
Q
Examples
A
- Heparin
- Enoxaparin, dalteparin
2
Q
Mechanism (Heparin, LMWH, Fondaparinoux)
A
Heparin: Increase efficacy of antithrombin III (X,II)
LMWH+Fondaparinoux: Increase efficacy antithrombin III of factor 10
3
Q
Antidote
A
- Protamine sulfate
4
Q
Indications
A
- VTE, MI
5
Q
SE
A
- Haemorrhage, Hyperkalaemial, Heparin induced thrombocytopenia (HIT)- immune mediated
6
Q
CI
A
- Haemorrhagic disorders, renal impairment, hepatic impairment
7
Q
Monitoring
A
- FBC; Platelets - discontinue if >30% reduction
8
Q
Interactions
A
- NSAIDs, antiplatelets
- ARB’s, ACEi - hyperkalaemia
