Morphine/codeine

Question 1

Class

Answer 1

• Opiate

Question 2

SE

Answer 2

Common: Constipation, n/v, ureteric spasm

Important: Resp depression(‘Kop’ receptors), Hypotension (vasodilation), addiction, coma

Question 3

Tx of overdose

Answer 3

Naloxone

Question 4

CI

Answer 4

Obstructive bowel disorders, prostatic hypertrophy, shock, ARDS, renal impairment

Question 5

Mechanism

Answer 5

• Bind to opioid ‘mu’ receptors in CNS Hyperpolarise neuron -> Inhibit asc./desc. pain signals