Hepatitis

Question 1

What is Hepatitis B susceptible to?

Answer 1

Bile acid lysis

Question 2

Which pegylated IFN treats HBV?

Answer 2

pegIFN a2a

Question 3

What is the MOA of IFN for HBV treatment?

Answer 3

Acts as host cytokine

Has antiviral, antiproliferative, and immunomodulatory effects

Question 4

What are some warnings associated w/ Adevovir Dipivoxil?

Answer 4

1. Nephrotoxicity

2. Increase of serum creatinine

Question 5

Telbivudine is a(n) _______ analogue with potent anti-HBV activity

Answer 5

L-nucleoside

Question 6

Hepatitis is a (DNA/RNA) virus

Answer 6

DNA, partially double stranded

Question 7

Interferon alpha AE?

Answer 7

1. Flu-like symptoms
2. Neuropsychiatric events
3. Risk for infection
4. Increased liver enzymes
5. Stevens-Johnson Syndrome

Question 8

Sofosobuvir AE?

Answer 8

Rash + pruritus + anemia

Question 9

For HCV, what class does Sofosobuvir belong to?

Answer 9

NS5B inhibitor

Question 10

What are the main treatments for HBV?

Answer 10

IFN (standard or pegylated)

Question 11

For HCV, what class does Grazoprevir belong to?

Answer 11

Protease inhibitor

Question 12

Ribavirin MOA and what is it used against?

Answer 12

Inhibits RNA polymerase + inhibits initiation/elongation of RNA fragments

For HCV

Question 13

Interferon alpha MOA?

Answer 13

Naturally producing cytokine that has antiviral, antiproliferative, and immunomodulatory effects

Question 14

What drugs are made up in the NS5B inhibitor class used against HCV?

Answer 14

End w/ “buvir”

1. Sofosobuvir
2. Dasabuvir

Question 15

What is the MOA of Lamivudine?

Answer 15

Inhibits DNA polymerase

Question 16

Which RX inhibits lamivudine resistant HBV?

Answer 16

Adefovir Dipivoxil, Entecavir, or Telbivudine

Question 17

For HCV, what class does Dasabuvir belong to?

Answer 17

NS5B inhibitor

Question 18

For HCV, what class does Elbasvir belong to?

Answer 18

NS5A inhibitor

Question 19

For HCV, what class does Paritaprevir belong to?

Answer 19

Protease inhibitor

Question 20

NS5A inhibitor MOA?

Answer 20

Binds to N terminus within domain 1 to inhibit replication + assembly

Question 21

For HCV, what class does Ledipasvir belong to?

Answer 21

NS5A inhibitor

Question 22

For HCV, what class does Daclatasvir belong to?

Answer 22

NS5A inhibitor

Question 23

For HCV, what class does Simeprevir belong to?

Answer 23

Protease inhibitor

Question 24

Rivavirin AE?

Answer 24

1. Hemolytic anemia
2. CNS effects
3. GI effects
4. Dermatologic effects
5. Neuromuscular effects

Question 25

What is the MOA of Adefovir Dipivoxil?

Answer 25

Inhibits DNA polymerase

Question 26

Which standard IFN treats HCV?

Answer 26

IFN a2a or IFN a2b

Question 27

What drugs are made up in protease inhibitors that are used against HCV?

Answer 27

End w/ "previr" 1. Grazoprevir 2. Paritaprevir 3. Simeprevir

Question 28

Protease inhibitors used for HCV, AE?

Answer 28

1. General stuff | 2. Skin photosensitivity + rash

Question 29

What is the first line therapy for chronic HBV?

Answer 29

Entecavir + Tenofovir

Question 30

Which pegylated IFN treats both HBV and HCV?

Answer 30

pegIFN a2a

Question 31

Which treatment of HBV can develop resistance as a result of prolonged treatment?

Answer 31

Lamivudine + Telbivudine

Question 32

For HCV, what class does Ombitasvir belong to?

Answer 32

NS5A inhibitor

Question 33

For HCV, what class does Velpatasvir belong to?

Answer 33

NS5A inhibitor

Question 34

Which standard IFN treats HBV?

Answer 34

IFN a2b

Question 35

Protease inhibitors used for HCV, MOA?

Answer 35

Binds to HCV protease to inhibit viral replication

Question 36

Dasabuvir MOA and what is it used against?

Answer 36

Non-nuclodside polymerase inhibitor HCV

Question 37

Which standard IFN treats both HBV and HCV?

Answer 37

IFN a2b

Question 38

Dasabuvir AE?

Answer 38

Rash + puritis

Question 39

Which pegylated IFN treats HCV?

Answer 39

pegIFN a2a or pegIFN a2b

Question 40

What drugs are made up in the NS5A inhibitor class used against HCV?

Answer 40

End w/ "svir"

Question 41

NS5A AE?

Answer 41

Anemia

Question 42

What is the MOA of Entecavir?

Answer 42

Inhibits HBV by: 1. Prime DNA polymerase 2. Reverse transcriptase 3. DNA synthesis

Question 43

Which RX is superior to adefovir?

Answer 43

Tenofovir

Question 44

Adefovir Dipivoxil is a nucleoside analog converted to __________ intracellularly

Answer 44

diphosphate

Question 45

Sofosobuvir MOA and what is it used against?

Answer 45

Nucleoside polymerase inhibitor HCV

Question 46

What are the main drugs used in treating HCV?

Answer 46

1. Ribavirin 2. Interferon-alpha (no longer used) 3. Protease inhibitors 4. NS5B inhibitors 5. NS5A inhibitors