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Flashcards in Hepatitis testing Deck (6)
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1

What are ground-glass hepatocytes? 

What are they suggestive of?

  • Ground-glass hepatocytes can be seen on light microscopy as hepatocytes with flat, hazy and uniformly dull appearing cytoplasms

*This is thought to be because of the presence of hepatitis B surface antigen (HBsAg) inside the endoplasmic reticulum.

  • They point towards a diagnosis of chronic hepatitis B infection and are not present in acute infection

2

What does surface antigen (HbsAg) mean?

HbsAg (surface antigen) → active infection

3

What does E antigen (HBeAg) mean?

HBeAg (E antigen) → marker for viral replication (high infectivity)

4

What do core antibodies (HBcAb) mean?

HBcAb (core antibodies) → past or current infection 

5

What does surface antibody (HBsAb) mean?

Surface antibody (HBsAb) → vaccination or past or current infection 

6

What does Hepatitis B virus DNA (HBV DNA) mean?

HBV DNA → direct count of viral load