Hepatitis viridae Flashcards Preview

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Flashcards in Hepatitis viridae Deck (36):
1

what are the primary viruses that infect liver

RNA:Hep A
Hep C
Hep D
Hep E
Hep G
DNA: HepB

2

What hepatitis are fecal-oral route

A and E

3

what hep viruses can lead to chronic hepatitis

B C and D

4

presentation of acute viral hepatitis

flue, fatigue, low fever, aches, cough, rhinitis and pharyngitis
1-2 weeks late jaundice (high bliirubin)
increase in AST ALT GGt and alkaline phosphatase

5

Why is chronic viral hep hard to Dx

asymptomatic with enlarged tender liver and mildy elevated liver function enzymes

6

describe the liver enzyme levels in viral hepatitis in relation to each other

the ALT and ASt will be high
GGT and alkaline phosphatase, bilirubin moderately high
bilirubin continues to rise

7

describe liver enzyme levels in say gallstone obstruction

bilirubin, alkaline phosphatase and GGT are higher than AST ALT

8

Describe composition of Hep A

naked cosahedral capsid with + ss RNA
part of Picornaviridae
fecal-oral route

9

how long is the incubation period for Hep A before signs of acute hepatitis

15-40 days

10

How do you Dx Hep A

serologic tests for HepA capsid Ag

11

What is the composition of Hep B

large, enveloped icosahedral capsid with ds circular DNA

12

What is the name of the intact Hep B virus

Dane Particle

13

What are the filamentous structures on the Dane Particles of Hep B

hepatitis B surface Ag HBsAg

14

What is HBeAg

the component of the Hep B core that is released in active infection

15

How is HBV spread

blood to blood,
parenteral

16

What disease states can be caused by HBV

acute hepatitis
fulminant hepatitis
chronic hepatitis
co-infection with hep D virus

17

what is fulminant hepatitis

severe acute hep with rapid destruction of liver

18

what are the 3 states of chronic hepatitis

asymptomatic
chronic persistent- low grade
chronic active- acute hepatitis 6-12 months

19

how does liver injury occur in hepatitis

cell mediated because Viral Ag are targets for CTLs and the IC can deposit leading to arthritis and kidney damage

20

Why are immunocompromised patients usually carriers without symptoms of Hep B

because their immune system does not attack

21

what can occur if HBV is incorporated into Host DNA

primary hepatocellular carcinoma
cirrhosis

22

Detection of what Ag means there is a live Hep B virus and infection

HBsAg

23

detection of anti HBsAg means what in hep B

immune, cure, no active disease

24

If patient has IgM anti HBcAg what does this say?
What about IgG antiHBcAg

IgM is new infection
IgG is old infection

25

how do we monitor high infectivity vs low infectivity of Hep B

high is presence of HBeAg
low is presence of anti HBeAg

26

Hep D needs what to replicate

help of Hep B becauses uses Hep B envelope

27

HBsAg Ab are protective for what viruses

Hep B and D

28

what occurs with HDV infecting a person with chronic Hep B

superinfection
cirrhosis, greater mortality
remains chronically infected

29

What is the leading cause of chronic hepatitis in US, leading indication for liver transplantation

hep C

30

What is the composition of Hep C

enveloped icosahedral RNA in falvivirus family
genotype 1 is most common in US

31

Presentation of Hep C

incubation 6-12 weeks
asymptomatic but some have acute hepatitis
85% develop chronic hepatitis

32

How do we Dx Hep C

anti HCV Ab detectable 6-8 weeks after exposure

33

How do we confirm Dx of Hep C

recombinant immunoblast assay
RIBA
or measuring HCV viral RNA

34

Where is Hep E endemic

Asia, India, Arica and Central America

35

What family is Hep G from

flavivirus

36

Hep B is apart of what family of DNA viruses

hepadna