Rest of the RNA viruses Flashcards Preview

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Flashcards in Rest of the RNA viruses Deck (68):
1

what are the arboviruses

toga, flavi and bunya

2

The west nile virus is apart of what family

flavi

3

what is the large gorup of enteroviruses

picornaviruses
polio, coxsackie A and B, echovirus and new enteroviruses

4

What viruses cause rhinitis

rhinovirus and coronavirus

5

What does SARS stand for and what type of virus is it

severe acute respiratory syndrome part of the coronaviruses

6

rotaviruses and caliciviruses generally cause what

diarrhea

7

What virus causes rhabies

rhabdo

8

What are the viruses that cause hemorrhagic fever

Ebola and Marburg
part of the filoviruses
also Arenavirus- lassa fever

9

what are the 2 types of togaviruses and presentations

alpha which cause encephalitis and inflammation of brain with fever, HA and altered levels consciousness
rubivirus causing rubella

10

What are the 3 alpha togaviruses

Wester equine encephalitis
Eastern ""
Venezuelen ""

11

Patient from africa bit by mosquito now has fever rash and severe joint swelling and pain
likley Dx?

chikungunya- toga virus that does not cause encephalitis

12

What is rubella

mild febrile illness iwth rash

13

When is rubella clinically reallly dangerous

first trimester during pregnancy

14

What is the presentation of rubella

measles like
fever lymphadenopathy and flu like
rash from forehead to face to torso to extremities
onlys lasts 3 days

15

What can be caused by congenital rubella

chromosomal breakage and inhibition of mitosis
heart defects
eye cataracts, chorioretinitis
CNS mental retardation, microcephaly and deafness

16

Is the rubella vaccine give to pregnant women

no wait till immediately after birth

17

What is the second leading cause of viral encephalitis in US

St louis encephalitis- flavivirus family

18

What febrile diseases are caused by flaviviruses

yellow fever and dengue

19

what is the presentation of yello fever

hepatitis with jaundice
fever, backache, nausea and vomiting
Africa

20

What is the presentation of dengue

severe painful backache, muscle an djoint pain and severe HA
painful!

21

What sertype of dengue causes dengue hemorrhagic fever

serotype 2

22

What are the rare symptoms if any seen with WNV west nile

HA maculopapular rash
sometimes polio like motor symptoms or guillain Barre like

23

What gorup is most at risk with WNV infection? least?

most is immunocompromised
least is children

24

What ways can you Dx WNV

detection in culture
serum IgM
CSF IgM against WNV
4X increase in Ab titers

25

what is the most sensitive test for Dx west nile

serum or CSF IgM

26

What must be present to confirm Dx of WNV

neutralizing IgG Ab against WNV

27

What are characteristics of Bunyaviruses

fever and encephalitis

28

What is the vector for hanatavirus

usually rodent, deer mous for Sin nombre virus

29

What is the presentation of hantavirus pulmonary syndrome

high fevers, muscle aches, cough, nausea and vomiting
rapid HR and RR
high WBC, low platelets, high RBC

30

What is the confirmatory Dx for hantavirus pulmonar syndrome

serologic IgM and IgG Ab to sin nombre virus

31

What are the picorna viruses and where do they infect, how are they transmitted

entero, rhino, hepato and parceho
infect intestinal epithelial and lyphoid cells
excreted in feces and spread by fecal oral route

32

What are the 5 enteroviruses

polio
coxsackie A and B
echo
new enteroviruses

33

what cells does poliovirus infect

peyers patches of intestines
motor neurons

34

where does polio sprad to

CNS anterior horn of spinal f=cord

35

What are the 3 manifestations of polio

mild
aseptic meningitis
paralytic poliomyelitis

36

what is presentaiton of mild polio

asymptomatic infection
usually in infants living in poor sanitation

37

describe aseptic meningitis from polio

fever and meningismus
recover in 1 week

38

describe paralytic poliomyelitis

destruction of presynaptic motor neurons in anterior horn of SC and post synaptic neurons leaving th horn
no sensory losses usually

39

polio with paralysis is more sever in what age gorup

above 15 years

40

what polio vaccine has inactivated form? live attenuated?

formalin killed is Salk which is injection
Sabin is the oral attenuated poliovirus

41

which polio vaccine is used now in US

the salk one because sabin was assoc with causing paralytic polyiomyelitis in some instances

42

What do the coxsackie viruses, echo and new enteroviruses have in common

asymptomatic or mild febrile
respiratory symptoms
rashes
aseptic menintis

43

What are the most common causes of non-bacterial aseptic meningitis

enteroviruses

44

What does Coxsackie virus A cause

herpangina- fever sore thraot, small red vesicles on back of throat
hand foot and mouth syndrome- fever, oral vesicles and tender lesions on hands feet and buttocks

45

What does Coxsackie virus B cause

pleurodynia- fever, HA and severe lower thoracic pain on breathing (pleuritic)
myocarditis/pericarditis-self limited chest pain

46

What is the morphology of corona viruses

enveloped ss RNA viruses

47

Presentation of SARS

2-10 day incubation
fevers, myalgias, chills and dry cough, chest pain and SOB
abnormal Cardiograph or chest cT with consolidation

48

How do you Dx SARS

reverse transcriptase PCR for viral RNA in respiratory secretions, feces, urine and lung biopsy

49

The course of Gastroenteritis takes how long

1-2 incubation days
4-7 symptoms

50

presentation of caliciviruses

young children and infants
diarrhea, vomiting and fever

51

presentation of Norwalk virus

adults but usually children with diarrhea and severe vomiting

52

presentation of Norovirus

major cause of acute infectiou diarrheal outbreaks

53

What is rotavirus a cause of

acute diarrheal infection

54

What is intussusception

small intesting collapses inward- old roatvirus vaccine caused this

55

What cause periodic outbreaks of diarrhea in infants children and elderly

astroviruses

56

What is the shape of rhabdovirus

bullet shaped, enveloped and helical symmetry

57

what does rabies in humans lead to

fatal encephalitis

58

what are the brain cell changes in rabies

neuropathic changes and collection of virions in cytoplasm called negri bodies

59

Once rabies symptoms occur how long till death

1-2 weeks

60

What happens in prodromal period rabies

fever HA sore throat, fatigue, nausea, painfully sensitive nn around healed wound site

61

What is the second period of rabies infection after prodromal period

acute encephalitis with hyperactivity and agitation that leads to confusion, meningismus and seizures

62

why do people with rabies foam at mouth

CN dysfunction and painful contractions of pharyngeal mm that cases hydrophobia, inability to swallow fluids (saliva)

63

what ultimately causes death in rabies

respiratory dysfunction

64

what should you do if person bit from possibly rabid animal

clean with soap and water aggressviley

65

If bitten individual by animal is + for rabies then what do you do

give human rabies Ig with 5 injections of killed rabies virus vaccine
combine active and passive immunity

66

how is ebola and other viral hemorrhagiv fevers transmitted

definitely direct contact with bodily fluids but airborne ahs not been ruled out

67

What is critical in Tx ebola or marburg

BP support from capillary leakage

68

What viruses are apart of arenaviruses

lassa fever
junin virus
machupo
gunarito
sabia