Herpes Viruses Flashcards Preview

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Flashcards in Herpes Viruses Deck (40):
1

What holds the herpes viruses latent

cell mediated immune response

2

What effect of herpes viruses have on the immune system

cytopathic
become multinucleate syncytial cells with intranuclear inclusion bodies

3

where do the herpes viruses hang out being latent

in the sensory ganglia

4

what supset of herpes viruses cause cell destruction

the alpha group
herpes simplex 1 and 2
herpes zoster

5

what are the other herpes viruses and their corresponding subtypes

CMV is beta
EBV is gamma

6

how does transmission of herpes simplex 1 and 2 occur

direct inoculation of much-cutaneous surfaces

7

What are some of the clinical manifestations of herpes siplex

gingivostomatitis
genital herpes
herpetic keratitis
neonatal herpes
herpetic whitlow
disseminated herpes
encephalitis

8

what are the signs of gingivostomatitis

painful swollen gums and mucous membranes with vesicles
fever and systemic symptoms
resolve in 2 weeks

9

what are the signs of genital herpes

fever, HA, vaginal and urethral discharge
enlarge d lymph nodes
blisters and painful or painless ulcers

10

what is the most common infectious cause of corneal blindness in the US

herpetic keratitis

11

what can neonatal herpes cause

transplacental viral transfer
congenital defects or intrauterine death

12

What is herpetic whitlow

HSV infection of the finger that is painful, hot, swollen and red

13

when does disseminated herpes happen? and where?

immunocompromoised patients
liver, lung and GI

14

what is the most common cause of viral encephalitis in the US

HSV-1

15

what are the signs of HSV-1 encephalitis

fever and focal neurological abnormalities

16

What are the TORCHES that cross placenta

Toxoplasmosis
Rubella
CMV
Herpes HIV
Syphilis

17

where does varicell ainfect and what occurs

infects respiratory tract then after 2 week incubation causes viral dissemination in blood

18

What are symptoms of varicella infection

fever, malaise, HA with characteristic rash that starts on face and trunk then spreads to entire body

19

What does the rash look like in Varicella

rose petal with dew on top(fluid vesicle)
becomes cloudy and ruptures then scab over
arise in crops or patches

20

Patient has hard red lesions that have central depression and seem to be all over the body in the same state
likely Dx?

small pox

21

How does shingles or zoster occur

stressed state or lowered cell mediated immunity the latent varicella zoster virus replicates and migrates to cutaneous nn

22

does singles occur in adults that have not had chickenpox

no the adults contract chicken pox

23

what adult vaccine is recommended for control of shingles

live attenuated varicella vaccine for adults 60+ whether or not have had shingles

24

What can zoster lead to in immunocompromised patients

pneumonia and encephalitis

25

What 4 infectious states does CMV cause

asymptomatic
congenital
CMV mononucleosis
reactivation in immunocompromised

26

what can CMV cause if cross placenta

congenital disease includeing mental retardation, microcephaly, deafness, seizures, and other birth defects

27

What is CMV mononucleosis

young adults
like EBV
"monospot negative mono"

28

What can CMV cause in immunocompromised patients

retinitis blindness, pneumonia, disseminated infection and death

29

What occurs with AIDS patients and CMV

CMV retinitis

30

What occurs in marrow transplant recipients and CMV infection

CMV pneumonitis

31

What part of the blood culture do you look for CMV in

in the buffy coat because invades WBC

32

What ways can you Dx CMV

buddy coat
Ag detection in blood- only when virus is replicating
PCR- only when virus replicating

33

What is EBV

mononucleosis
B cell infection
transforms cells via entering Cd3'
makes huge cells that are pretty much malignant but spontaneous resolutino occurs

34

What cancer is assoc with EBV

B cell lymphoma

35

What is at high risk for Patients with Burkitt lymphoma

concurrent EBV infection which can lead to death

36

In an immunocompromised host what is at high risk if have EBV infection

lymphomas secondary to EBV reactivation

37

What are the symtoms of mono

fever, chills, sweats, HA and painful pharyngitis
enlarged lymph nodes and sometimes spleens

38

What does CBC look like for mono infection

high WBC with atypical lymphocytes
and heterophile Ab- which is against EBV anc causes agglutination

39

What is the monospot test

Looks for heterophile Ab that will cause agglutination of sheep RBC

40

morphology of herpes viruses

ds linear DNA enevloped and icosahedral