High Grade Astrocytoma Flashcards
(14 cards)
Aka
Anaplastic astrocytoma
Aligoblastoma multi formed
High grade are
Highly malignant, behave aggressive. Grow rapidly, destroy adjacent brain tissue
Can occasionally
Spread through CNS or to distant sites
High grade gliomas are typically
Supratentorial and are associated with rapidly progressing neurologic symptoms
Symptoms
Headaches
Lethargy
Motor or sensory loss
Seizures
On imaging
Irregular borders
Areas of necrosis
Surrounding edema
The lesions enhance with contrast because
Of their disruption of the BBB
Management of high grade astrocytoma requires
Multiple modalities
What’s the first step?
Neurosurgery
The goal of surgery
Complete resection although clear margins are difffiult to achieve
Surgery often provides
Immediate symptomatic relief. But residual tumor always remains.
Radiation therapy is commonly used
After surgery with temozolomide
Chemo is particular useful in infants because
Delay the need for radiation therapy while brain natures.
