Late Effects Of Trrestment

Question 1

The treatment of large areas of the brain and spinal cord in led patients can have a variety of

Answer 1

Devastating late sequelra

Question 2

Late effects are

Answer 2

Typically worse the younger the child is at time of treatment

Question 3

Radiation therapy is known to affect the

Answer 3

Microvasculature of the brain, as well as cells that produce myelin.

Question 4

When cells that produce myelin are effected it disrupts

Answer 4

Neurogenisis and causes cortical atrophy

Question 5

Patients may

Answer 5

Fail to acquire new knowledge and skills at age appropriate and progresssivve decline of IQ

Question 6

The end result for most patients is

Answer 6

Impaired school and school preformance that deteriorates over time

Question 7

Endocrine deficits are

Answer 7

Are common and correlate with the dose of radiation to the hypothalamic pituitary axis Impair vision

Question 8

CSI can also

Answer 8

Decrease the height of vertebral bodies

Question 9

Secondary malignancies

Answer 9

May develop years later in the bones and soft tissues and CNS or bone marrow as a result of rad and chemo