Neuroblastoma Flashcards
(24 cards)
Neuroblastoma is another
Small, round blue cell tumor derived of neural crest origin
These cells migrate
Embryononolgicslly to form paravertebrsl sympathetic ganglia, adrenal medulla, and peripheral nerves.
Neuroblastoma like cells
Can occur in fetal adrenal glands
Neuroblastoma is the most
Common extra cranial solid tumor
What gene is commonly associated with
N-myc and oncogene
Most occur in the
Abdomen, typically near midline with the origin in the adrenal gland (35%) or paraspinal ganglia (32%)
Invasion of the spinal canal can cause symptoms of
Neurologic compromise or SCC
Symptoms
Flushing, diarrhea, abdominal mass, liver Mets,
Approximately
60% present with Mets
Symptoms and Mets disease is varied
Fatigue
Anemia
Bleeding
Fever
Weight loss
The most common site of Mets is
Bone 50%
Patients with Neuroblastoma look
Younger an are sicker than wilms
Radiogrsphic and CT are used for
Revealing calcification in the mass
What is a classic feature of Neuroblastoma
Calcification
Low risk patients receive
Surgery and observation or chemo.
Intermediate risk withrespectable disease
Surgery
Chemo
RT
Intermediate with unresectsble
Induction chemo followed by surgery
Most patients present with high risk disease
Require aggressive treatment
Induction chemo and surgery
Myeoablative chemo
Stem cell transplant
RT
Immunotherapy
Patients with advanced diseases are
Rarely cured
Radiation therapists may
Palliatively treat patients who have progressive Mets.
Low dose of 1000 cGy
In the acute situation of newborn
Doses of only 500 cGY may be effective with no long term side effects
Lung fibrosis can occur with
Thoracic radiation
In older patients recovering more than 2000
Bones and soft tissue of treated region may have decreased development or asymmetric growth
