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Flashcards in High Risk Drugs Deck (68):
1

What is Carbimazole used for?

Hyperthyroidism

Report any sore throat, ulcers, fever, malaise, bleeding with Carbimazole

2

What is the difference between:

Agranulocytosis

Thrombocytopenia

Blood Dyscrasias

Agranulocytosis: WBC's go down; sore throat, fever, malaise all symptoms

Thrombocytopenia: Platelets go down: blood very thin: unexplained bleeding/ bruising. Can be from Heparins

Blood Dyscrasias: Entire blood profile goes down; symptoms of both of the above, this is why we report both sets of symptoms with some drugs

3

What is the loading dose of Amiodarone?

200mg TDS for 7 days

200mg BD for 7 days

Then 200mg OD from there on (maintenance)

Why load? Long half life (50 days) means it would take ages to reach therapeutic levels. Also means interactions can still occur months after stopping.

4

Symptoms of Aspirin Overdose (5)

Tinnitus

Hyperventilation

Deafness

Vasodilation

Sweating

 

5

Why is rifampicin considered High Risk do you think?

(Rifampicin is one of the TB drugs)

Many interactions- as it is an enzyme Inducer, it induces ALL of the CYP enzymes: decreases efficacy of COC's

HEPATOTOXIC: Monitor LFTs, counsel on liver toxicity signs, stop if:

Persistent Nausea
Vomiting
Malaise
Jaundice

Also colours urine/ body fluids/ soft contact lenses red/ orange

6

What monitoring is needed with Rifampicin?

LFT's before starting- continue to monitor if on prolonged therapy

Renal function before starting

FBC if on prolonged therapy

 

7

Which class of antibiotics do we need to use with caution in EPILEPTICS?

Quinolones-

Ciprofloxacin, Levofloxacin

These lower seizure threshold! 

Particularly if used with theophylline

8

Why do we need to check albumin levels with warfarin?

Warfarin is highly protein bound to albumin- if this is low there may be issues transporting it round the body

need to monitor both renal and liver function with warfarin 

9

People stable on warfarin- how often is INR checked?

Every 3 months

 

Unless changes in clinical status occur e.g. diarrhoea and vomitting 

10

What (quite unpleasant) side effects are associated with Amiodarone use, what signs should patients look out for? (7)

Nausea and vomitting and taste disurbance

Thyroid function- Hypo and Hyperthyroidism through action of IODINE in the drug

Phototoxic skin reactions: burning sensation, erythema, slate grey skin discolouration

Pulmonary toxicity- persisitent SOB/ Cough

Tremor- peripheral neuropathy- numbness in hands and feet

Corneal microdepositis in eyes- dazzled by headlights- common SE: this is reversible once drug stopped 

Liver toxicity: Jaundice

11

12

What 5 things need monitoring at baseline with Amiodarone?

LFT's- Hepatotoxicity a risk

THYROID FUNCTION- hyper/hypothyroidism 

Serum Potassium!!!! before starting

Chest X-ray- pulmonary toxicity

ECG with IV use

LFT's and TFT's need monitoring after 6 months too!

13

What is Amiodarone used for?

Treatment of

Both supraventricular and ventricular Arrhythmias

Ventricular fibrilation, ventricular tachycardia

Usually used when other drugs failed as quite a nasty drug

Rhythm control as part of pharmacological cardioversion in AF

14

Methotrexate inhibits dihydrofolate reductase and therefore reduces folate in the body. What drug has to be given with methotrexate as supplementation to prevent its nasty side effects, and when?

For prevention of methotrexate induced horrible side effects in Chron's/ RA:

Folic acid 5mg ONCE WEEKLY- dose to be taken on a DIFFERENT DAY to methotrexate

15

Methotrexate may lead to blood disorders (most significantly neutropenia and increased infection risk) through BONE MARROW SUPPRESSION. Its anti- folate propertied may explain how it suppresses bone marrow...

Bone marrow is where the body creates new cells. Cell division requires folate in order to occur. 

 Since folate deficiency limits cell division, erythropoiesis, production of red blood cells, WBC, neutrophils etc is suppressed in the bone marrow when methotrexate is taken as it is anti- folate. This is the same story as with Trimethoprim/ Co- trimoxazole and Phenytoin as these are also anti-folate- Avoid use together! 

Production of RBC's being hindered also leads to megaloblastic anemia, which is characterized by large immature red blood cells that cannot divide. 

16

What monitoring does Methotrexate require?

Renal function

LFT's 

FBC (due to blood disorder risk)

These should be 1-2 weekly until dose stabilised then 2-3 monthly thereafter

Exclude pregnancy- pregnancy test before starting?

Avoid in hepatic impairment and reduce dose in renal impairment unless severe- then avoid. 

17

What is Methotrexate used for?

Main use in:

Rhumatoid Arthritis

Severe Chron's (Inflammatory Bowel Disease)

Severe Psoriasis

It is cytotoxic- stops cell division- part of chemotherapy 

 

18

What are the Methotrexate warning signs 

Blood disorder: Bone marrow suppression- sore throat, ulcers, fever, rash

Liver toxicity- N&V, abdominal pain, dark urine, Jaundice

Gastro-intestinal toxcitiy: stomatitis, GI upset (sore mouth first symptom)

Pulmonary Toxicity- persistent SOB, cough

PREGNANCY & Breastfeeding- its anti-folate so avoid!!- contraception needed during treatment  and for 3 months after stopping

WITHDRAW TREATMENT IF ANY OF THESE OCCUR

19

What OTC med's can increase the risk of Methotrexate toxicity?

NSAIDS/ ASPIRIN !!
Reduce methotrexate excretion in kidney 

As do penicillins!

20

A patient comes in complaining of mouth sores, they think it may be cold sores. After further questioning you find out they are on Methotrexate. What do you do?

Advise they seek medical attention ASAP

Mouth sores may be a sign of stomatitis (inflammation of mouth) which is the first sign of Gastro-intestinal toxicity associated with Methotrexate!

21

A patient asks for some Lozenges as they are experiencing a very sore throat. You find out they are on Methotrexate. What do you do?

Seek medical attention ASAP

Sore throat is most common side of blood disorders with Methotrexate

22

Patients can sometimes overdose on Methotrexate as they get confused that it is Just once weekly dosing. What are the symptoms? what is methotrexate toxicity treated with?

Renal impairment

Liver impairment

Headache, seizures, coma

Treatment: FOLINIC ACID- rescues normal cells from methotrexate effects

 

23

What happens when Baclofen (used for pain of muscle spasms in palliative care/ trauma) is suddenly withdrawn? What if it is given with ACE inhibitors or Beta blockers?

Suddenly withdrawn: hyperactivity, hyperthermia, hallucinations, convulsions

Enhanced Hypotensive effects with ACEi/ Beta blockers

24

Which NOAC is contra-indicated in patients with a Prosthetic valve?

DABIGATRAN 

25

ORLISTAT (Alli)

26

What needs monitoring with Vancomycin (4)?

Full blood count: can cause both LOW PLATELETS and LOW NEUTROPHILS (Neutropenia)

Renal function- Nephrotoxic- Urinalysis, CrCl used for dosing

Hearing function in the elderly 

Plasma concentration

27

What needs monitoring with Gentamicin?

Renal function 

Hearing function

Plasma concentration

NB: differs to vancomycin as do not need to monitor FBC- does not cause neutropenia/ low platelets 

28

Which antihypertensive drugs require the SAME BRAND to be maintained?

Diltiazem

Nefedipine

(Both CCB's)

29

Which CCB cannot be used in both Supraventricular and Ventricular arrhythmias?

VERAPAMIL

Used for Supraventricular only

 

Verapamil NOT to be used in Ventricular Arrhythmias

30

Ciclosporin (an immunosuppressant drug) has many interactions. This is because it is toxic to many organs, so any drug effecting each of those organs will be contra-indicated with ciclosporin use. What toxicitys can it cause (5)?

Neurotoxicity (CNS- tremor, convulsions, encephalopathy)

Liver toxicity (jaundice, N&V, abdo pain, dark urine)

Nephrotoxicity (kidney)

Blood toxicity/ disorders (fever, sore throat, ulcers, bleeding)

Hypertension- BP needs monitoring regularly

Patient should report any of these signs

31

What type of vaccines are Ciclosporin and Tacrolimus Contra-indicated with?

Live vaccines

Live vaccines can, in some situations, cause severe or fatal infections in immunosuppressed individuals due to extensive replication of the vaccine strain that the immune system cannot fight off.

 

Same goes with high dose corticosteroids: these can suppress the immune system so avoid live vaccines

32

What should patients on corticosteroids be told with regards to chickenpox/ measels?

If they have not have these before, avoid any exposure to anyone with these as they can contract very severe forms of these if they do. 

33

Why is an eye exam needed with corticosteroid use?

Risk of eye problems:

Glaucoma- look for intraocular pressure

Corneal thinning

34

What drugs can increase the risk of someone developing gout (build up of uric acid)?

Diuretics– clears excess fluid out of body but the remaining fluid is more concentrated; increases the risk of developing the crystals that cause gout

Beta-blockers and ACE inhibitors

low-dose aspirin – used to reduce the risk of blood clots

niacin – used to treat high cholesterol

ciclosporin – used to treat conditions such as psoriasis

35

What are the symptoms of gout?

What are the dietary risk factors of gout?

Build up of uric acid causing:

sudden attack of severe pain in one or more joints, typically big toe.

joint feeling hot and very tender, swelling in and around the affected joint

Dietary risk factors: high in meat and seafood and high in beverages sweetened with fructose promotes higher levels of uric acid, also alcohol.

Phospohorus can help cure gout: Banana is a rich source of phosphorus. 

36

What is the main symptom of Hypokaleamia?

What drugs can cause hypokaleamia?

Ventricular Arrhythmias

(Hyperkaleamia can also cause arrhythmias!)

Thiazide, thiazide-like and Loop diuretics

Sotalol

Salbutamol

Amisulpiride 

Atomoxetine (used for ADHD)

37

Can you inject potassium chloride 20% w/v straight?

No- must be diluted first with sodium chloride 0.9% 
Must be given by slow infusion

Monitor ECG- rapid infusion would be toxic to heart and arrhythmias occur 

Need to the patient is weeing enough- contraindicated in anuria (absence of urination) as potassium would build up 

38

What could black stools or coffee groung vomit be suggestive of with NSAIDs? What about Iron deficient aneamia?

GI bleeding

39

What are the following indicative of with NSAID therapy?

Unexplained weight loss

difficulty swallowing

nausea or vomiting

bloating

burping or acid reflux- recent onset dyspepsia

Peptic ulcer

40

What could swollen ankles indicated with NSAID therapy?

Kidney failure

41

Which NSAID is now contra-indicated in patients with a cardiac disease history/ risk of CV disease?

Diclofenac

The new treatment advice applies to systemic formulations (ie, tablets, capsules, suppositories, and injection available both on prescription and via a pharmacy, P); it does not apply to topical (ie, gel or cream) formulations of diclofenac.

42

What electrolyte disturbance could NSAIDs effectively cause?

NSAIDs can damage the kidneys (AKI)

This can in turn lead to HYPERKALEAMIA 

43

A dose increase for an opioid should be no more than __% of the last dose

No more than 50%

Due to risk of overdose

44

Aside from their use in pain, what else can strong Opioids be used for?

Relief of breathlessness in palliative care

Relief of breathlessness and anxiety in acute pulmonary oedema (alongside oxygen, furosemide, nitrates)- Myocardial infarction

But do not give them in respiratory failure!

Suprising when they can cause respiratory depression! This is because they reduce cardiac work and oxygen demand- hence their use in Myocardial Infarction. 

45

What side effects do opioids have on the skin?

They cause histamine release- this can cause ITCHING and urticaria (hives/ nettle rash), also sweating 

46

Biliary colic is a type of pain related to the gallbladder that occurs when a gallstone obstructs the cystic duct and the gallbladder contracts. Should we use opioids for this pain?

No- opioids can worsen the pain due to sphincter spasm

47

How is chronic pain usually managed with strong opioids?

Oral route first:
Start with an immediate release solution such as Oramorph 

Then once optimal dose found- switch to modified release (MST Continus- administered BD [12 hourly])

For breakthrough pain, immediate release (Oramorph) morphine at a dose of 1/6 the usual. 

48

Why must codeine/ dihydrocodeine never be given via the IV route?

Can cause a severe reaction similar to anaphylaxis (but not allergy based) 

49

Which opioid should be avoided in epileptics?

Tramadol: it lowers the seizure threshold

 

Avoid with other drugs that lower seizure threshold: SSRI's, TCA's, quinolones, theophylline

50

What is heaviness in the centre of the chest likely to indicate?

Heart attack

51

How should oral antiplatelets be administered?

With or just after food (to protect stomach)

Except for Dipyridamole: 30 to 60 mins before food

52

Why is Tacrolimus such a high risk drug? What can it cause?

Hint: Similar to Ciclosporin. Both toxic to many organs

Neurotoxicity (CNS)- tremor, headache

Nephrotoxicity 

Eye disorders (ciclosporin not toxic to eyes)

Blood disorders- report fever, sore throat, ulcers etc

Skin disorders- rash

Hyperglycaemia 

Liver toxicity

53

What dietary substances should patients on Tacrolimus / Ciclosporin avoid?

Avoid a diet high in Potassium (as these can BOTH cause Hyperkaleamia)

Avoid grapefruit juice- Increases plasma concentrations of these as its an enzyme inhibitor

54

What drugs can cause Hyperkaleamia?

Ace inhibitors/ ARBs

Potassium sparing diuretics (spironolactone + eplerenone)

Ciclosporin and Tacrolimus (immunosuppressants)

NSAIDs

55

What do we use to treat hyperkaleamia?

Calcium gluconate

The priority is to stabilise the heart: do not want it to arrest due to fatal cardiac arrhythmias 

Then sort out hyperkaleamis:

IV insulin or salbutamol as temporary measures to drive K+ back into cells

If its severe- use Heamodialysis

Why not use diuretics, as these cause hypokaleamia too?- as diuretics will effect fluid balance. do not want to put any more strain on the heart.

56

What should a patient do if they miss a warfarin dose?

Do not double up!

 

If later that evening- take dose. If next day- skip dose

57

Why are beta blockers used with caution in diabetes?

Can mask hypoglyceamia:

 beta blockers blunt the of adrenalin: if someone becomes hypoglycemia adrenalin doesnt kick in and they dont get warning symptoms. Sweating is the only symptom that still shows.

Can also prevent adrenalin from stimulating the liver to make glucose, and therefore may make the hypoglycemia more severe

58

Why are beta blockers cautioned in asthma and COPD?

Risk of bronchospasm

If absolutely need one: choose a cardio selective BB like Bisoprolol

59

Why do we get a dry cough with Ace inhibitors and not ARB's?

ARB's do not increase bradykinin levels, because they do not inhibit ACE

60

Why are NSAID's cautioned in asthma, what can they cause?

Bronchospasm- does not happen to every asthmatic. 

61

Which diuretics can exacerbate diabetes?

Thiazides (most likely)
Loop diuretics

Due to hyperglyceamia side effect!

62

What do we need to monitor with diurectic use?

Electrolytes:
Na +

K +

Mg +

Renal function

Uric acid levels (risk of gout)

Hyperglyceamia- can exacerbate diabetes

Hypotension- BP lowering effects

63

When do we use simvastatin at a max dose of 10mg?

With fibrate use in combo: massive risk of myopathy

+ Bezafibrate

+ Ciprfibrate

Do not use gemfibrozil at all- risk of Rhabdomylosis too great

64

Which oral antidiabetic carries the least risk of Hypoglyceamia?

Metformin

65

What vitamin deficiency can Metformin cause? 

Vitamin B12 (cobalamin)

Symptoms of deficiency:

neuropathy (numbness, pain, or tingling in hands or feet)

Anaemia-

extreme tiredness (fatigue)

lack of energy (lethargy)

breathlessness

pale skin

66

Ace inhibitors have some protective and some negative effects on the Kidneys. When are they contra- indicated?

Bilateral Renal artery stenosis - they will make it progress into renal failure

Less effect on Unilateral renal artery stenosis

Best to avoid in patients with known or suspected RENOVASCULAR disease

 

67

What is the max daily dose of Codeine?

How long must intervals between doses be?

,Max number of days OTC?

240mg daiy

6 hour intervals

3 days OTC

68

What drug causes 'Purple glove syndrome' skin disease in which the extremities become swollen, discoloured and painful

Phenytoin if given IV