Histamine & Serotonin - Side Effects

Question 1

Cyproheptadine

Answer 1

sedation; anti-muscarinic effects

Question 2

Chloropheniramine

Answer 2

sedation, but less so

Question 3

Promethazine

Answer 3

sedation; anti-muscarinic effects

Question 4

Diphenhydramine

Answer 4

sedation; anti-muscarinic effects

Question 5

Loratidine

Answer 5

cardiovascular effects at high doses

fewer sedative and CNS effects because it poorly crosses BBB

Question 6

Fexofenadine

Answer 6

cardiovascular effects at high doses

fewer sedative and CNS effects because it poorly crosses BBB

Question 7

Azelastine

Answer 7

fewer sedative and CNS effects because it poorly crosses BBB

Question 8

Cetrizine

Answer 8

fewer sedative CNS effects because it poorly crosses BBB

Question 9

Cimetidine

Answer 9

most side effects of H2 receptor antagonists

1. anti-androgen activity canc ause impotence and gynecomastia
2. inhibition of P450 enzymes
3. possible CNS dysfunction

Question 10

Ranitidine

Answer 10

1. liver toxicity

2. possible CNS dysfunction

Question 11

Famotidine

Answer 11

possible CNS dysfunction

Question 12

Nizatidine

Answer 12

possible CNS dysfunction

Question 13

Methysergide

Answer 13

1. GI disturbances
2. inflammatory fibrosis
3. hallucinations