histo rheum

Question 1

histological findings for sarcoid

Answer 1

non caseating granulomas asteroid bodies Schaumann bodies

Question 2

investigations for Sarcoid

Answer 2

raised Ca Raised ESR raised ACE Kveim test historically- intradermal injection of splenic sarcoid tissue and resultant granuloma formation

Question 3

extra pulomary symptoms for sarcoid

Answer 3

weight loss night sweats hypercalcaemia/ hypercalciuria arthritis bone cysts erythema nodosum lupus pernio skin nodules ant/ post uveitis uveoparotid fever

Question 4

what is uveoparotid fever

Answer 4

Heerfordt syndrome facial palsy bilateral uveitis parotid enlargment

Question 5

amyloidosis

Answer 5

multisystem disease where misfolded proteins are deposited as fibrils in healthy tissue

Question 6

primary amyloidosis protein

Answer 6

amyloid L

Question 7

secondary amyloidosis protein

Answer 7

amyloid A

Question 8

secondary amyloidosis associations

Answer 8

RA, ank spond TB renal cell carcinoma hodgkin lymphoma

Question 9

familial amyloidosis alternative name

Answer 9

familial mediterranean fever

Question 10

defect in familial mediterranean fever

Answer 10

pyrin gene overproduction of IL1

Question 11

protein in haemodialysis associated amyloidosis

Answer 11

beta 2 microglobulin

Question 12

diagnosis of amyloidosis

Answer 12

apple green bifringence under polarised light witha congo red stain

Question 13

what causes the findings under polarised light in amyloidosis

Answer 13

beta sheets and the fibrils self assort as they are unstable

Question 14

symptoms of amyloidosis

Answer 14

nephotic syndrome cardiac arrythmia carpal tunnel hepatosplenomegaly macroglossia in 10%

Question 15

what are the large vessel vasculitides

Answer 15

temporal arteritis takayasu’s arteritis

Question 16

who gets takayasu’s arteritis

Answer 16

middle aged japenese women

Question 17

sx of takayasu’s arteritis

Answer 17

bruits pulseless disease claudications

Question 18

temporal arteritis symptoms

Answer 18

jaw claudication scalp tenderness raised ESR

Question 19

histology of temporal arteritis

Answer 19

granulomatous transmural inflammation

Question 20

WHAT IS SEEN ON ANGIOPATHY OF POLYARTERITIS NODOSA

Answer 20

MICROANEURYSMS

Question 21

what disease predisposes you to PAN

Answer 21

hep B

Question 23

SLE reaction type

Answer 23

type 3 hypersesitivity

Question 24

autoantibodies in SLE

Answer 24

anti dsDNA antism anti histone ANA

Question 25

hisotlogy of SLE

Answer 25

lupus erythematosus cell onion skin lesion in splenn libman sacks endocarditis microangiopathy in CNS

Question 26

symptoms of SLE 4 of SOAP BRAIN MD

Answer 26

serositis Oral ulcers Arthritis Photosensitivity Blood disorders e.g. AIHA,lecopenia, ITP Renal involvment ANA +ve Immune pheonomena e..g antidsDNA ab Neuro sx malar rash discoid rash

Question 27

HLA association ion SLE

Answer 27

HLA DR3 (or2)

Question 28

HLA association for limited or diffuse scleroderma

Answer 28

HLA DR5 and DRw8

Question 29

autoantibodie in limited scleroderma

Answer 29

anti centromere

Question 30

sx oflimited scleroderma

Answer 30

calcinosis raynauds oesophageal dysmotility Sclerodactyly telangectasia pulm HTN

Question 31

histology of limited scleroderma

Answer 31

onion skinning of arteries increased collagen in skin and organs

Question 32

autoantibodies in diffuse scleroderma

Answer 32

anti scl-70 fibrillarin RNA polyermase I, II, III PM-Scl

Question 33

histology of diffuse scleroserma

Answer 33

inflammation within and around muscle fibres

Question 34

sx of diffuse scleroderma

Answer 34

skin and organ changes pulmonary fibrosis

Question 35

dermatomyositis and polymyositis autoantibody

Answer 35

anit-Jo1

Question 36

whatis anti Jo1

Answer 36

tRNA synthase

Question 37

polymyositis histology

Answer 37

endomysial inflammatoary infiltrate

Question 38

dermatomyositis histology

Answer 38

capilliary and myofibre damage

Question 39

sx of dermatomyositis and polymyositis

Answer 39

proximal muscle weakness abnormal EMG raised CK

Question 40

dermatomyositis cutaneous features

Answer 40

gotten papules on hands heliotrope rash on eyes

Question 41

what is associated with dermatomyositis and polymyositis

Answer 41

underlying malignancy

Question 42

what condition is associated with dermatomyositis

Answer 42

pulmonary fibrosis

Question 43

difference between pemphigus and pemphigoid

Answer 43

pemphigoid forms subepidermal bullae and pehmigus forms intraepidermal IgG is linier in pemphigoid and netlike in pemphigus in pemphigoid the IgG binds to intercellular hemi desmosomes onBM whereas in pemphigus the IgG binds to demosomal proeteins