HLA ASSOCIATIONS

Question 1

What are HLA antigens

Answer 1

HLA antigens are encoded for by genes on chromosome 6.

HLA A, B and C are class I antigens

whilst DP, DQ, DR are class II antigens.

Question 2

What condition is associated with HLA-A3

Answer 2

haemochromatosis

Question 3

HLA-B51

Answer 3

Bechet’s

Question 4

HLA-B27 (x3)

Answer 4

ankylosing spondylitis
reactive arthritis
acute anterior uveitis

Question 5

HLA-DQ2/DQ8

Answer 5

coeliacs disease

Question 6

HLA-DR2

Answer 6

narcolepsy

good pastures

Question 7

HLA-DR3

Answer 7

dermatitis herpetiformis

Sjogren’s syndrome

primary biliary cirrhosis

Question 8

HLA-DR4

Answer 8

T1DM - and HLA-DR3

RA

Question 9

which particular gene in regards to RA

Answer 9

DRB1 gene