1
Q
What is histamine?
Identify:
Definition
Cellular structures it is found
A
Chemical messenger found in high concentrations in mast cells, basophils, and CNS neurons
2
Q
Where does histamine occur in our body/tissues?
Identify:
Tissues with most histamine
A
Occurs in most tissues but is unevenly distributed
High amounts found in the lungs, skin, and GI tract
3
Q
What cellular responses does histamine mediate?
A
- Allergic and inflammatory reactions
- Gastric acid secretion
4
Q
Describe the allergic and inflammatory reaction
- Allergic response initiation and response
- Inflammatory response components
A
- Allergens initiate allergic response
- Mast cells rupture and degranulate, releasing large quantities of histamine
- Mediators initiate the inflammatory response - prostaglandins, histamine, leukotrienes, cytokines, eosinophil chemotactic factor
