Flashcards in HPV: Ryan Deck (6)
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1
Describe the HPV serotypes associated with benign anogenital warts and those at high risk for transformation to cancer.
HPV 6 and 11 benign
HPV 16 and 18 high risk for cancer
2
What are the two viral proteins responsible for binding and ultimately removing or inactivating two tumor suppressor proteins p53 and RB?
E6 and E7
3
Is the cancer associated with HPV derived from permissive or non-permissive cells? Explain why.
Non-permissive. Late gene expression does not occur, and instead of virus production, infxn leads to the transformation of cells.
4
Explain how warts form.
Virus infects cells in the germinal cells in the basal layer of the epidermis. These cells are non-permissive and are transformed. As they move to the surface of the skin, they become permissive and shed virus (hence the contagion). These transformed cells replicate as a tumor and form the wart.
5
Describe the DNA and structure of the HPV.
Circular, double-stranded DNA genome.
Non-enveloped icosahedral capsid.
6
