Flashcards in HPV: Ryan Deck (6)
Describe the HPV serotypes associated with benign anogenital warts and those at high risk for transformation to cancer.
HPV 6 and 11 benign
HPV 16 and 18 high risk for cancer
What are the two viral proteins responsible for binding and ultimately removing or inactivating two tumor suppressor proteins p53 and RB?
E6 and E7
Is the cancer associated with HPV derived from permissive or non-permissive cells? Explain why.
Non-permissive. Late gene expression does not occur, and instead of virus production, infxn leads to the transformation of cells.
Explain how warts form.
Virus infects cells in the germinal cells in the basal layer of the epidermis. These cells are non-permissive and are transformed. As they move to the surface of the skin, they become permissive and shed virus (hence the contagion). These transformed cells replicate as a tumor and form the wart.
Describe the DNA and structure of the HPV.
Circular, double-stranded DNA genome.
Non-enveloped icosahedral capsid.