Hyper X Syndrome Flashcards
(6 cards)
1
Q
Where is Hyper X found in?
A
Only men
2
Q
What Hyper X caused by?
A
Defective CD40L expressed on activated T cell
3
Q
What does a defective CD40L prevent?
A
Iso-type class switching
4
Q
What does X linked Hyper IgM syndrome cause?
A
- Overproduction of IgM
- Stops signal 2 from being transmitted and proliferation from occurring
5
Q
What are the symptoms of X linked Hyper IgM syndrome?
A
- Sinus infection
- Ear infection
- Diarrhoea
- Failure to grow
- Low levels of neutrophils
6
Q
What does X linked Hyper IgM syndrome lead to?
A
Pyogenic infection (E.g CMV, Pneumocystis)
