Immune Synapse Flashcards
(8 cards)
1
Q
What is SMAC (Supra-molecular activation cluster)
A
Focuses T cells and APCs into a concentrated area receptors involved acting as sealing rings to prevent escape of cytolytic agents
2
Q
What is the different rings in the immune synapse
A
Central SMAC, Peripheral SMAC, Distal SMAC, Cytotoxic SMAC
3
Q
What is found on the Central SMAC?
A
TDR/CD3 microclusters and costimulatory molecules (e.g CD28)
4
Q
What is found on the Peripheral SMAC?
A
LFA-1. ICAM-1
5
Q
What activates LFA-1?
A
TCR signals
6
Q
What is found on the Distal SMAC?
A
CD45
7
Q
What is found on the Cytotoxic SMAC?
A
CTL and targets
8
Q
What does Cytotoxic SMAC allow?
A
Enables targeted secretion of cytotoxic granules (containing granzymes and perforin)
