LAD I (Leukocyte Adhesion Deficiency) Flashcards
(5 cards)
1
Q
What is the cause of LAD I?
A
Lack of gene CD18 beta subunit of the B2 integrin
2
Q
Why can’t Diapedesis be done?
A
No CD-18
3
Q
What is the symptoms of LAD I?
A
Recurrent bacterial infection
Delayed wound healing
Raised WBC in blood
Systemic infections
Skin infections
4
Q
How to diagnosis LAD I
A
- Leucocytosis
- Flow cytometric analysis of integrins
- Phagocyte functional studies
5
Q
How to treat LAD I?
A
- Bone marrow transplant
- Prophylactic of antibiotics
