IBD Flashcards
(26 cards)
with mesalazine what is the main therapeutic agent for UC
5asa
why is mesalazine better tollerated that sulphursalazine
no sulphur
what does mesalazine block
COX
what does mesalazine inhibit the production of
prostoglandins in the colon
what does hydrocortisone bind to
cortisol receptor
what happens after hydrocortisone has bound to a cell
translocates to the nucleus, binds to glucocorticoid response elements (GRE) in the promoter region of the target genes, causing the increase in their expression
what does hydrocortisone increase the expression of
lipocortins
what do lipocortins do
inhibit phospholipase A2
what happens if there is less phospholipase A2
less arachidonic acid synthesis and production of inflammatory mediators
other ways corticosteroids calm inflammation
decrease in the function of the lymphatic system
reduction in immunoglobulin and complement concentrations
interference with antigen-antibody binding
what is prednisolone derives from
cortisone
where is prednisolone metabolised
liver duh
steroids for IBD
hydrocortisone
prednisolone
budesonide
what drug has a higher binding affinity to glucocorticoid receptor
budesonide
azathioprine inhibits
purine synthesis
azathioprine MOA
incorporation of thiopurine analogues into the DNA structure, causing chain termination and cytotoxicity
azthioprine worst side effect
bone marrow suppression
what should you avoid giving with azathioprine
purine anologues e.g. allopurinol
ciclosporin binds to
cyclophilin
what does inhibition of cyclophilin cause
inhibition of calcineurin
what does lack of calineurin mean
cant produce IL2
what is infliximab
TNF-alpha blocker
what does infliximab bind to
soluble subunit and the membrane-bound precursor of TNF-α
what does infliximab cause lysis of
cells that produce TNF-α
