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Flashcards in IBD Drugs Deck (12):
1

prototypical IBD anti-inflammatory:

not absorbed --> active in gut (including small intestine)

Mesalamine (5-ASA)

2

Balsalazide

ASA based

anti-inflammatory

must be activated by gut bacteria -- local action in colon

3

Olsalazine

ASA based

anti-inflammatory

activated by gut bacteria -- local action in colon

4

Sulfasalazine

side fx:

ASA based

anti-inflammatory

activated by gut bacteria -- local action in colon

Side fx:
-hypersensitivity (sulfa)

-GI upset

-nausea/HA

-bone marrow suppression

-decreased folate

5

Corticosteroid with low bioavailability --> good for Crohn's

budesonide

6

Indications for ASA's:

mild to moderate ulcerate colitis

**not good for Crohn's dt disease severity and lack of dose amount at site

7

Anti-TNF-a

activates complement

Infliximab

8

Immune sys response problematic with Infliximab tx:

can develop Ab's to drug

9

Side Fx's of Infliximab:

increased risk of infx

infusion rxn

hepatotoxic

increased lymphoma risk

TB reactivation

10

Second line IBD

anti-metabolites (3):

azathioprine

6-MP

MTX

11

Last line against refractory IBD before surgery:

Infliximab

12

4 treatment strategies for IBD from mild - severe disease:

mild:
topical corticosteroids

abx

5-ASA

moderate:
MTX

6-MP

AZAthioprine

oral corticosteroids

Severe:
anti-TNF-a

cyclosporine

IV-corticosteroids

Refractory to med managment:

surgery