Flashcards in Wk1 Protein and Lipids Deck (49):
Pepsinogen --> ____?____ --> Pepsin
Trypsinogen > ? > Trypsin
Chymotrypsinogen > ? > Chymotrypsin
Proelastase > ? > Elastase
Procarboxypeptidases > ? > carboxypeptidases
Exo vs Endo peptidases?
Exo -- cleave bonds on the end of peptide chains
Endo -- cleave bonds within peptide chains
Why do CF patients have trouble absorbing protein?
Blockage of pancreatic duct
How do AA get from lumen into cells?
**Na conc gradient generated by Na/K ATPase
How do AAs get from epithelial cells into blood?
Transporter for tryptophan
Bo aka SLC6A9
What happens if pt is SLC6A9 deficient?
What are the three hallmark sx of Hartnup disease?
Hartnup disease causes pellagra d/t lack of production of what?
(without SLC6A9 can't absorb tryptophan to synthesize niacin)
Niacin is an important component of which molecules:
Mutation of SLC7A9 (Bo+) or causes?
**loss of basic AA (Arg, Lys, His)
What does cystinuria cause?
Two transporter mutation that cause cystinuria?
1. SLC7A9 (Bo+)
2. SLC3A1 (rBAT)
Route for AA absorption but not important for majority of dietary AA uptake?
rx with glutathione via gama-glutamyl transpepsidase
4 fates of AAs once they are in the cell:
1. Protein synth
2. N-containing compounds
3. Urea cycle
4. C for TCA cycle
activates protein synthesis and inhibits autophagy
activiates lipid metabolism
inhibits mTORC1 and ACC
Protein deficiency with normal calorie intake?
3 jobs in AA metabolism?
3. carbon chain transfers
PLP deficiency causes?
Job in AA metabolism?
one carbon transfers
FH4 deficiency causes what?
Job in AA metabolism?
BH4 deficiency causes what?
Two hormones that promote secretion of bile and lipase:
Triacylglycerol + pancreatic lipase --> ?
2 fatty acids + 2-monoacylglycerol
What does PLA-2 do?
Where does it come from?
cuts the #2 fatty acid from phospholipids
Breaks down big balls of fat into little balls of fat:
What happens to fatty acids once in the gut epithelial cells?
Converted back to TAG
Packaged as nascent chylomicrons and dumped into lymphatics
Apoprotein of nascent chylomicrons:
Where do they get this?
From RER in epithelial cells before going to lymph
How do you get ApoB-48 from same DNA as ApoB-100?
What do nascent chylomicrons get once they enter the blood?
Where do they get it?
What activates LPL to cut FAs from chylomicrons?
What happens to chylomicron remnants in the liver?
repackaged with ApoB-100 as VLDL
What do adipocytes need to store FAs?
glycerol 3-phosphate backbones from glycolysis
**so they can only store in fed state
Fat transport molecules from largest to smallest:
Chylomicron (huge by comparison)
Transfer DIETARY fat from gut to tissue:
Transfer fat produced by dietary CARBS to tissue:
Where do VLDL come from:
In charge of cholesterol and apoprotein homeostasis:
Source of HDL:
liver and intestine
Whats is it?
What is it?