Wk1 Protein and Lipids Flashcards Preview

GI > Wk1 Protein and Lipids > Flashcards

Flashcards in Wk1 Protein and Lipids Deck (49)
Loading flashcards...
1

Pepsinogen --> ____?____ --> Pepsin

H+

2

Trypsinogen > ? > Trypsin

Enteropepsidase

3

Chymotrypsinogen > ? > Chymotrypsin

trypsin

4

Proelastase > ? > Elastase

trypsin

5

Procarboxypeptidases > ? > carboxypeptidases

trypsin

6

Exo vs Endo peptidases?

Exo -- cleave bonds on the end of peptide chains

Endo -- cleave bonds within peptide chains

7

Why do CF patients have trouble absorbing protein?

Blockage of pancreatic duct

8

How do AA get from lumen into cells?

Na+ symporter

**Na conc gradient generated by Na/K ATPase

9

How do AAs get from epithelial cells into blood?

Facilitated transport

10

***

Transporter for tryptophan

Bo aka SLC6A9

11

***

What happens if pt is SLC6A9 deficient?

Hartnup disease

12

***

What are the three hallmark sx of Hartnup disease?

1. Dementia

2. Dermatitis

3. Diarrhea

13

Hartnup disease causes pellagra d/t lack of production of what?

niacin

(without SLC6A9 can't absorb tryptophan to synthesize niacin)

14

Niacin is an important component of which molecules:

NADH

NADPH

15

***

Mutation of SLC7A9 (Bo+) or causes?

cystinuria

**loss of basic AA (Arg, Lys, His)

16

What does cystinuria cause?

kidney stones

17

***

Two transporter mutation that cause cystinuria?

1. SLC7A9 (Bo+)

2. SLC3A1 (rBAT)

18

Route for AA absorption but not important for majority of dietary AA uptake?

rx with glutathione via gama-glutamyl transpepsidase

19

4 fates of AAs once they are in the cell:

1. Protein synth

2. N-containing compounds

3. Urea cycle

4. C for TCA cycle

20

mTORC1?

activates protein synthesis and inhibits autophagy

21

ACC ?

activiates lipid metabolism

22

AMPK ?

inhibits mTORC1 and ACC

promotes autophagy

23

Protein deficiency with normal calorie intake?

kwashiorkor

24

PLP

3 jobs in AA metabolism?

1. transaminations

2. deaminations

3. carbon chain transfers

25

PLP deficiency causes?

seizures

diarrhea

anemia

EEG abnormalities

26

FH4

Job in AA metabolism?

one carbon transfers

27

FH4 deficiency causes what?

megaloblastic anemia

28

BH4

Job in AA metabolism?

ring hydroxylations

29

BH4 deficiency causes what?

seizures

developmental delays

30

Two hormones that promote secretion of bile and lipase:

secretin

cholecystokinin