Wk1 Protein and Lipids Flashcards Preview

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Flashcards in Wk1 Protein and Lipids Deck (49):
1

Pepsinogen --> ____?____ --> Pepsin

H+

2

Trypsinogen > ? > Trypsin

Enteropepsidase

3

Chymotrypsinogen > ? > Chymotrypsin

trypsin

4

Proelastase > ? > Elastase

trypsin

5

Procarboxypeptidases > ? > carboxypeptidases

trypsin

6

Exo vs Endo peptidases?

Exo -- cleave bonds on the end of peptide chains

Endo -- cleave bonds within peptide chains

7

Why do CF patients have trouble absorbing protein?

Blockage of pancreatic duct

8

How do AA get from lumen into cells?

Na+ symporter

**Na conc gradient generated by Na/K ATPase

9

How do AAs get from epithelial cells into blood?

Facilitated transport

10

***

Transporter for tryptophan

Bo aka SLC6A9

11

***

What happens if pt is SLC6A9 deficient?

Hartnup disease

12

***

What are the three hallmark sx of Hartnup disease?

1. Dementia

2. Dermatitis

3. Diarrhea

13

Hartnup disease causes pellagra d/t lack of production of what?

niacin

(without SLC6A9 can't absorb tryptophan to synthesize niacin)

14

Niacin is an important component of which molecules:

NADH

NADPH

15

***

Mutation of SLC7A9 (Bo+) or causes?

cystinuria

**loss of basic AA (Arg, Lys, His)

16

What does cystinuria cause?

kidney stones

17

***

Two transporter mutation that cause cystinuria?

1. SLC7A9 (Bo+)

2. SLC3A1 (rBAT)

18

Route for AA absorption but not important for majority of dietary AA uptake?

rx with glutathione via gama-glutamyl transpepsidase

19

4 fates of AAs once they are in the cell:

1. Protein synth

2. N-containing compounds

3. Urea cycle

4. C for TCA cycle

20

mTORC1?

activates protein synthesis and inhibits autophagy

21

ACC ?

activiates lipid metabolism

22

AMPK ?

inhibits mTORC1 and ACC

promotes autophagy

23

Protein deficiency with normal calorie intake?

kwashiorkor

24

PLP

3 jobs in AA metabolism?

1. transaminations

2. deaminations

3. carbon chain transfers

25

PLP deficiency causes?

seizures

diarrhea

anemia

EEG abnormalities

26

FH4

Job in AA metabolism?

one carbon transfers

27

FH4 deficiency causes what?

megaloblastic anemia

28

BH4

Job in AA metabolism?

ring hydroxylations

29

BH4 deficiency causes what?

seizures

developmental delays

30

Two hormones that promote secretion of bile and lipase:

secretin

cholecystokinin

31

Triacylglycerol + pancreatic lipase --> ?

2 fatty acids + 2-monoacylglycerol

32

What does PLA-2 do?

Where does it come from?

cuts the #2 fatty acid from phospholipids

pancreas

33

Breaks down big balls of fat into little balls of fat:

bile salts

34

What happens to fatty acids once in the gut epithelial cells?

Converted back to TAG

Packaged as nascent chylomicrons and dumped into lymphatics

35

Apoprotein of nascent chylomicrons:

Where do they get this?

ApoB-48

From RER in epithelial cells before going to lymph

36

How do you get ApoB-48 from same DNA as ApoB-100?

RNA editing

37

What do nascent chylomicrons get once they enter the blood?

Where do they get it?

ApoCII

ApoE

--from HDL

38

What activates LPL to cut FAs from chylomicrons?

ApoCII

39

What happens to chylomicron remnants in the liver?

repackaged with ApoB-100 as VLDL

40

What do adipocytes need to store FAs?

glycerol 3-phosphate backbones from glycolysis

**so they can only store in fed state

41

Fat transport molecules from largest to smallest:

Chylomicron (huge by comparison)

VLDL

ILDL

LDL

HDL

42

Transfer DIETARY fat from gut to tissue:

chylomicrons

43

Transfer fat produced by dietary CARBS to tissue:

VLDL

44

Where do VLDL come from:

Liver

45

In charge of cholesterol and apoprotein homeostasis:

HDL

46

Source of HDL:

liver and intestine

47

ApoB48
ApoCII
ApoE

Whats is it?

Chylomicron

48

ApoB100
ApoCII
ApoE

What is it?

VLDL

(or ILDL)

49

ApoB100

What is it?

LDL