Wk4 Anti-emetics Flashcards Preview

GI > Wk4 Anti-emetics > Flashcards

Flashcards in Wk4 Anti-emetics Deck (28):
1

Binds toxin in upper GI

acute tx of poisoning

activated charcoal

2

Induces vomiting

no longer used

Ipecac

3

Lower GI

cathartic

decontaminating agent

polyethylene glycol solution

4

Best tx for chemo nausea

given before chemo

5HT3 inhibitors

-setrons

dolasetron
granisetron
ondansetron (zofran)
palonosetron

5

Three H1 antagonists

cause sedation

Dimenhydrinate

Diphenhydramine

Meclizine

6

Anticholinergic

some D2 antagonism also

best for motion sickness

acts on cerebellum

transdermal to decrease side fx

scopolamine

7

Two NK1 antagonists (substance P)

chemo N/V

given with 5HT3's + dex

CYP3A4 can interact with some chemo drugs

APREPITANT

fosAPREPITANT

8

D2 antagonists (5)

cause sedation

droperidole

metaclopramide

prochlorperazine

promethazine

thiethylperazine

9

Two corticosteroids

MOA: unknown in nausea

given with 5HT3s and NK1s in chemo

dexamethazone

methylpredisolone

10

act on central cannabinoid receptors

dronabinol

nabilone

11

Dolasetron

Granisetron

Ondansetron

Palonosetron

5HT3 antagonists

act mostly in GI

some vomiting center and chemoreceptor activity
-"redundancy"

Best given BEFORE chemo

Acute phase -- first 24 hrs

12

Dimenhydrinate

H1 antagonist

causes sedation

**maybe some anticholinergic

13

Diphenhydramine

H1 antagonist

causes sedation

**maybe some anticholinergic

14

Meclizine

H1 antagonist

causes sedation

**maybe some anticholinergic

15

Scopolamine

Anticholinergic

Motion sickness

cerebellum

some D2 action

transdermal patch decreases side fx

16

Aprepitan

Fosaprepitan

NK1 (substance P) antagonists

chemo N/V

given with 5HT3's and dex

CYP3A4 --> chemo interactions

17

Droperidol

D2 antagonist

sedation

18

Metoclopramide

D2 antagonist

sedation

19

Prochlorperazine

D2 antagonist

sedation

20

Promethazine

D2 antagonist

sedation

21

Thiethylperazine

D2 antagonist

sedation

22

Dronabinol

canniboid receptors

23

Nabilone

canniboid receptors

24

Important antiemetic receptors in cerebellum:

muscarinics

H1's

25

Important antiemetic receptors in Solitary tract nucleus

muscarinic

H1

also have 5HT3 and D2

26

Important receptors in higher centers:

NK1

cannabinoid

27

Important receptor in vomiting center

muscarinic

also have:

5HT3

D2

28

Important receptors in chemoreceptive trigger zone:

5HT3

D2

opiod

also have:

M1

H1