II - Acute and Chronic Inflammation (with pics) Flashcards Preview

Topnotch Patho Flash Cards 2016 > II - Acute and Chronic Inflammation (with pics) > Flashcards

Flashcards in II - Acute and Chronic Inflammation (with pics) Deck (96)
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61

Platelet-activating factor (PAF) is a phospholipid-derived mediator that is now known to have multiple inflammatory effects. What are these?

Platelet aggregration, vasoconstriction (vasodilation in low concentration), bronchoconstriction, and increased venular permeability. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 89

62

Enzyme blocked by NSAIDS.

Cyclooxygenase 1 and 2 (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 85 *SEE SLIDE 2.6

63

Enzyme inhibited by glucocorticoids

Phospholipase A2 (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 85 *SEE SLIDE 2.6

64

Polypeptide products of many cell types that function as mediators of inflammation and immune response.

Cytokines (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 86

65

They are a family of small structurally related proteins that act primarily as chemoattractants for different subsets of leukocytes.

Chemokines (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 87

66

Major cytokines in acute inflmmation.

TNF and IL-1 (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 86

67

A short-lived, soluble, free-radical gas produced by endothelial cells causing smooth muscle relaxation and vasodilation.

Nitric oxide (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 80

68

This component of the coagulation cascade initiates four systems involved in the inflammatory response, namely the kinin, clotting, fibrinolytic and complement systems.

Activated Hageman Factor / Factor XIIa(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.52

69

Inflammation characterized by infiltration with mononuclear cells, tissue destruction and repair involving angiogenesis and fibrosis.

Chronic Inflammation(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 93-94

70

Macrophages in the liver

Kupffer cells (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 94

71

Macrophages in the spleen and lymph nodes

Sinus histiocytes(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 94

72

Macrophages in the CNS

Microglial cells (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 94

73

Pathway of macrophage activation induced by microbial products such as endotoxin, cytokines, or foreign substance to produce substance for host defense and inflammatory reactions

Classical pathway. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 94

74

Pathway of macrophage activation induced by cytokines produced by T lymphocytes and other cells with the principal function of tissue repair.

Alternative pathway. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 95

75

Macrophages in the lungs

Alveolar Macrophages (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 94

76

Central amorphous granular debris, loss of all cellular detail, acid-fast bacilli *SEE SLIDE 2.2

Caseating tuberculosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.56

77

Acid-fast bacilli in macrophages, noncaseating granulomas

Leprosy(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.56

78

Microscopic to visible lesion, enclosing wall of histiocytes, plasma cell infiltrates, necrotic central cells without loss of cellular outline

Gumma (Syphilis)(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.56

79

Rounded or stellate granuloma containing central granular debris and recognizable neutrophils, giant cells uncommon.

Cat-scratch Disease(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.56

80

Noncaseating granulomas with abundant activated macrophages *SEE SLIDE 2.5

Sarcoidosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.56

81

Occasional noncaseating granulomas in intestinal walls, with dense chronic inflammatory infiltrate *SEE SLIDE 2.3

Crohn's disease(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.56

82

Cells with pink, granular cytoplasm with indistinct boundaries.

Epithelioid cells (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 98

83

40-50 um in size, consisting of a large mass of cytoplasm and many nuclei. *SEE SLIDE 2.4

Giant cells (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 98

84

Cytokines which stimulate prostaglandins in the hypothalamus, producing fever.

TNF, IL-1(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.57

85

A form of chronic inflammation characterized by collections of activated macrophages, often with T lymphocytes.

Granulomatous inflammation. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 98

86

Diseases with granulomatous inflammation

TB, Leprosy, syphilis, cat-scratch disease, sarcoidosis, Crohn's disease, systemic mycoses (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 98

87

True or false. Schistosomiasis may cause granulomatous inflammation

True. (TOPNOTCH)

88

True or false. Histoplasmosis may cause granulomatous inflammation

True. (TOPNOTCH)

89

A 5 y/o child touches a lit candle and develops a small blister on his right hand. The blister is an example of what type of inflammation?

Serous inflammation. (TOPNOTCH)

90

The hallmark of chronic inflammation

Tissue destruction (TOPNOTCH)