IL4 Flashcards
(19 cards)
What is the ratio of phospholipid, cholesterol, and glycolipid in the RBC membrane?
Phospholipid: Cholesterol: Glycolipid = 6: 3: 1
This ratio indicates the composition of the lipid bilayer in red blood cells.
How does cholesterol affect phospholipid movement at high temperatures?
Cholesterol interferes with the movement of the phospholipid fatty acid chains
Cholesterol stabilizes the membrane structure under varying temperature conditions.
What is the role of scramblase in the RBC membrane?
Moves phospholipids across membranes
Scramblase helps maintain membrane asymmetry and fluidity.
What is the consequence of a defect in the lipid membrane?
Can cause target cell issues and malaria can cause the membrane to become thinner
Membrane integrity is crucial for cell function and survival.
What are integral proteins in the RBC membrane?
Band 3, Glycophorin A, Glycophorin B, and Glycophorin C
Integral proteins span the membrane and are involved in transport and signaling.
What is the function of Band 3 in the RBC membrane?
Anion channel, maintains osmotic pressure
Band 3 is crucial for ion exchange and maintaining cell shape.
What role does glycophorin A play in the RBC membrane?
Generates charge
Glycophorin A contributes to the negative charge on the surface of RBCs.
What is the function of spectrin in the RBC membrane?
Maintains biconcave shape
Spectrin forms a cytoskeletal network that supports the membrane structure.
What is hereditary spherocytosis primarily caused by?
Ankyrin deficiency or abnormalities, alpha-beta-spectrin deficiency or abnormalities, band 3 abnormalities
These defects affect the RBC shape and stability.
What leads to hereditary elliptocytosis?
Alpha-beta-spectrin mutants leading to defective spectrin dimer formation and defective spectrin-ankyrin association
These mutations disrupt the normal structure of red blood cells.
What is South-East Asian ovalocytosis associated with?
Band 3 deletion
This condition affects the shape and function of red blood cells.
What proteins are involved in vertical interaction in the RBC membrane?
Cholesterol, ankyrin, tropomyosin
These proteins help maintain the structural integrity of the membrane.
What proteins are involved in horizontal interaction in the RBC membrane?
Spectrin, actin, protein 4.1
These proteins are crucial for the cytoskeletal organization of the membrane.
Fill in the blank: The RBC membrane protein involved in glucose transport is _______.
Glut 1
Glut 1 is essential for the uptake of glucose into red blood cells.
What role does glycophorin A play in the RBC membrane?
Generates charge
Glycophorin A contributes to the negative charge on the surface of RBCs.
What is the function of spectrin in the RBC membrane?
Maintains biconcave shape
Spectrin forms a cytoskeletal network that supports the membrane structure.
What is hereditary spherocytosis primarily caused by?
Ankyrin deficiency or abnormalities, alpha-beta-spectrin deficiency or abnormalities, band 3 abnormalities
These defects affect the RBC shape and stability.
What leads to hereditary elliptocytosis?
Alpha-beta-spectrin mutants leading to defective spectrin dimer formation and defective spectrin-ankyrin association
These mutations disrupt the normal structure of red blood cells.
What is South-East Asian ovalocytosis associated with?
Band 3 deletion
This condition affects the shape and function of red blood cells.
