immune system

Question 1

humoral immunity

Answer 1

serum/cell free. antibodies

Question 2

cell mediated immunity

Answer 2

doesnt involve antibodies

• phagocytes
• t lymphocytes
• cytokines

Question 3

what is cell mediated immunity directed at?

Answer 3

microbes that survive in macrophages and microbes that infect non-phagocytic host cells

Question 4

what is the cell mediated immunity most effective ar removing

Answer 4

virus infected cells

Question 5

what does cell mediated immunity play a major role in

Answer 5

transplant rejection

Question 6

cellular components of innate immune system

Answer 6

phagocytes

• granulocytes
• macrophages
• dendritic cells
• nk cells

Question 7

granulocyte function

Answer 7

respond rapidly and in large number

- eat until die

Question 8

macrophages

Answer 8

respond slower but live longer/larger and alert rest of immune system

Question 9

dendritic cells

Answer 9

• activate rest of immune system

- filter body fluid

Question 10

humoeral componenet of innate immune system

Answer 10

physical barriers
cytokines
enzymes
inflmm mediators
interferons
completment proteins

Question 11

interferon

Answer 11

relseased by dying virus-infected cells and inhibit viral rep in other cells

Question 12

effects of complement proteins

Answer 12

bacterial opsonization
direct cell lysis
chemotaxis

Question 13

function of b lymphocytes

Answer 13

antibody preod ytion

Question 14

cellular components of adaptive immunity

Answer 14

b and t lymphocytes

Question 15

function og T lymphocytes

Answer 15

antigen specific cewll medicatied immunity

Question 16

helper t cells

Answer 16

• cd4

- iniatiate/modulate activity of: B cells, NK, cytotoxic, macrophages via cytokines

Question 17

regulator T cells

Answer 17

supress/down regulate induction/proliferation of NK cells

- maintain tolerance of self antigens

Question 18

TH1

Answer 18

intracellular

• secrete inferon y and TNF a
• activate macrophages to kill microbes in phagosomes and active cytotox t cells
• stium b cells to secrete IgG

Question 19

TH2

Answer 19

extracellular

• secrete interluekens (2,4,10,13)
• stimulate C cells to make IgG that bond to mast cells, basophils, and eosinophils
• release local mediators

Question 20

cytotoxic T cells

Answer 20

cd8

induce apoptosis of cells with foreign epitopes

Question 21

anergy

Answer 21

state of immune unreposnisivness

Question 22

causes of anergy

Answer 22

b or t cell blocked from reacting with antigen because preventing from replicating or because in a state of immune tolerance

Question 23

when can anergy be seen

Answer 23

malnutrition, old age, HIV, DM

Question 24

what is a sign of an immune compromised patient

Answer 24

persistant oral thrush or cutaneous fungal infection

- infections that are difficult to cure or fend off