Malignancies Flashcards
(37 cards)
what is leukemia
neoplastic disorder of the blood and bone marrow
where are neoplastic cells derived?
myeloid or lymphoid cell lines
what are the subtypes of leukemia
chronic and acute
what is lymphoma
solid tumor in RES, mostly the lymph nodes
where does lymphoma come from
neoplastic lymphoid cells
clinical manifestation of leukemia
fatigue, MSK pain, HA
CBC leukemia
elevated WBC, decreased RBC/platelets
what is needed for a definitive diagnosis of leukemia
bone marrow biopsy
why would a lumbar puncture be preformed on someone with leukemia
to rule out CNS involvment
who gets AML
most common in adults
predisposing factors for AML
male
smoker
genetic (DS and trisomy 8)
findings in AML
auer rods in cytoplasm of the myeloblasts
prognosis for AML
varies with age
cause of CML
high dose radition
what is CML associated with
Philadelphia chromosome
findings in CML
basophilia and generalized granulocytosis with immature forms
CML treatment
Gleevec, stem/bone cell transplant
prognosis of CML
depends on stage at diagnosis and age
who gets ALL
children, white
prognosis of ALL
most favorable in kids
peak incidence of ALL
2-5
risk factor for ALL
down sydrome
lymphadenopathy associated with malignancy
non-tender, solid and immobile
findings in ALL
anemia, thrombocytopenia, low/normal wbc, lymphoblasts on smear
