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Flashcards in immunity and inflammation Deck (23):
1

what are the four classifications of hypersensitivity?

Types 1-4

2

type 1

IgE mediated

3

Type 2

tissue specific
specific to cell or tissue and no other sign of cell mediated
IgG and IgM mediated
grave's disease
blood agglutination

4

type 3

immune complex mediated

5

type 4

cell mediated

6

which types is a response to an allergen?

type 1

7

allergen

an antigen that causes an allergic reaction; typically foreign proteins from the environment

8

what are some common allergens

gluten
animal dander
pollen
rag weed
dust mites
milk protein

9

what are characteristics of a type 1 allergic hypersensitivity?

hives
bronchiole constriction
diarrhea
skin irritation

10

which type of allergic reaction leads to anaphylactic shock?

type 1

11

what are the characteristics of anaphylactic shock?

vasodilation
peripheral pooling
relative hypovolemia
decreases tissue perfusion
impaired cellular metabolism

12

what would you give someone to reverse the effects of anaphylactic shock?

epinephrine

13

tissue specificity

all tissue have specific markers or receptors

14

what are the five steps of type 2 hypersensitivity?

before the five steps there is antibody binding
1-complement mediated lysis
2.phagocytosis by macrophage
3-neutrophil-mediated damage
4-antibody-dependent cell-mediated cytotoxicity (NK cells)
5-cellular malfunction

15

in type 3, rather than binding to specific antigen (as in type2), on tissues...

effects are mediated by large complexes of antibodies

16

type 3 causes

complement activation
not organ specific
tissue damage

17

type 3 symptoms have little to do with

antigen

18

type 4 recruits

WBC to destroy antigen

19

what is an example of type 4?

contact dermatitis (poison IV)

20

is it an allergy?

yes, so then type 1
IgE mediated
asthma, hay fever, etc.

21

are there anybodies?

no-type 4
yes-types 2 or 3

22

is there binding

type 2

23

is there complexing?

type 3