Flashcards in Cardio Disorders Deck (132)
disease of the heart and/or blood vessels
heart disease is considered a consequence of
what are the effects of atherosclerosis?
thickening and hardening in the artery wall
what causes the effects of atherosclerosis?
thickening and hardening is caused by an accumulation of lipid-laden macrophages in the arterial wall.
increased inflammation signals
atherosclerosis is a consequence and cause of
increased blood pressure
atherosclerosis increases risk of
atherosclerosis is thought to stem from
what does high blood pressure cause?
tearing of endothelium and therefore inflammation.
turbulent flow in a blood vessel
where is turbulent flow most apparent?
in areas of branching or constriction of the blood vessel
turbulent flow damages:
A type LDL cholesterol is
large and less dense
B type LDL cholesterol is
Small and more dense
what are the risk factors for pattern B LDL cholesterol
what can increase your levels of patten B LDL cholesterol?
a very low fat high carb diet
dietary cholesterol has ____ impact on blood cholesterol
increased consumption leads to ____ absorption
where does most circulating cholesterol come from?
it is synthesized de novo
where is cholesterol synthesized?
80% in the liver
10% in intestine
5% in skin
what is the most potent activator of de novo cholesterol synthesis?
what is related to increased cholesterol synthesis?
increased fasting insulin.
what increases cholesterol synthesis from the liver?
what are the most widely prescribed drug in the world?
HMG-CoA reductase inhibitors
what do HMG-CoA reductase do?
they play a role in synthesizing cholesterol in the liver.
which group of people do statins help the most?
people with previous history of cardiovascular event. They don't really help other people
what are some of the side effects of statins?
increased risk of diabetes (T2)
muscle pain (muscle break down)
what is normal blood pressure
what is prehypertension BP?
What is stage one (primary) hypertension BP?