Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

2nd Time Through > Immuno > Flashcards

Immuno Flashcards

(71 cards)

Start Studying
1
Q

Lymph node - dense follicle vs follicles with pale central pallor?

A

inactive (primary) vs active (secondary)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

lymph node Medulla - parts and function?

A

1) cords - plasma cells

2) Sinuses - macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Part of lymph node not well developed in DiGeorge syndrome?

A

ParaCTX (t-cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Speen - location of T vs B cell?

A

Periarterial vs follicles in white pulp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Splenic dysfuntion - susceptible to? Why?

A

decreased IgM decreases complement activation and opsonization; increased susceptability to Encapsulated organisms -

SHiNE SKiS
strep pneumo, h flu, neisseria, Ecoli, salmonella, klebsiella,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Thymus - negative vs positive selection?

A

center (mature cells) vs periphery (immature cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Embryological origin of thymus vs lympocytes?

A

3rd brachial pouch vs mesenchyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

RBCs - how to kill infected cells?

A

NK cells. No MHC so no cytotoxicresponse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MHC I receptor consists of?

A 
a peptide (for binding)
B2 microglobulin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MHCII only present on what cells?

A

APCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

HLA: A3

A

Hemochromatosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

HLA: DR2

A

MS, hay fever, SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

HLA: DR3

A

DM 1, graves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

HLA: DR4

A

DM 1, RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

HLA: DR5

A

Hashimotos and pernicious anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Only lymphocyte member of innate immune response? Activity enhanced by?

A

NK cells. IL-2, IL-12, IFN-B, IFN-a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

T helper cell induced by?

A

IL-12 to become Th1

IL-4 to become Th2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

TLRs on what cells? bind to? Activation triggers?

A

Macrophages and DCs; PAMPS; release of NFkB which increases acute inflam response genes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

T cell receptor complex?

A

TLR and CD3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Only APC to activate naive T-cell?

A

DC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Necessary signals for T activation vs B-cell activation?

A

1) MHC I presentation by DC
2) B7 and CD28 costimulatory signal
vs
1) MHC II presentation by CD4 cell
2) CD40-CD40 costimulatory signal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

B-cells class switching determined by?

A

Cytokines released by Th cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Th1 vs Th2
1 secretion of?
2 Activates?
3 Inhibited by?

A

1 IFN-y vs IL-4,5,10,13
2 Macrophages/CD8 vs Esosinophils and IgE production
3 IL4,5 vs IFN-y

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

How do macrophages and lympcytes stimulate one another?

A

Macrophage releases IL-1, TNF-a

Lymhpocytes release INF-y

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
CD8 kills by?
Releasing perforin and granzyme
26
CD3, CD4, CD25 cell. funtion?
regulatory T-cell. Decrease response. Secrete IL-10 and TGF-B
27
Complement binds to what Igs?
IgM and IgG
28
Fc portion - describe
Constant, Carboxy terminal, Complement binding, Carbohydrate side chains
29
Igs expressed on B-cell surfaces?
IgG and IgM
30
Exposure to new antigen - when is IgG detected?
~10 days
31
Role of C3b, C3a, C5a, C5b
opsonization, anaphylaxis, anaphylaxis and neutrophil chemotaxis, MAC complex
32
Inhibitors of complement cascade?
DAF and C1 esterase inhibitor
33
IL-1 causes? secreted by?
1 fever, inflam 2 activates endothelium to express adhesion factors 3 induces cytokine secretion 4 activates osteoclasts macrophages
34
IL-6 function? secreted by?
actute-phase reactants | macrophages
35
IL-8? secreted by?
Chemotactic factor for neutrophils | macrophages
36
IL-12? secreted by?
1 induces T-cells to become Th1 2 activates NK cells Secreted by
37
TNF-a? secreted by?
Shock, leukocyte recruitment and vascular leak macrophages
38
IL-2? secreted by?
Growth of T-cells Antitumor effects of NK cells all T-cells
39
IL-3? secreted by?
increases bone marrow stem cell differentiation. functions like GM-CSF. all T-cells
40
IFN-y? secreted by?
activates macrophages and Th1 cells. suppresses Th2 cells. Th1 cells
41
IL-4? secreted by?
``` differentiation into Th2 cells. B-cell growth class switching to IgE and IgG ``` Th2 cells
42
IL-5? secreted by?
differentiation of B cells. increases IgA Growth of eosinophils Th2 cells
43
IL-10? secreted by?
Inhibits actions of activated T-cells. Th2 cells
44
IFN a vs b vs y
a/b inhibit viral protein synthesis | y increases MHC I and II expression and antigen presentation
45
Common T cell surface proteins? Seen in helper T-cells? Cytotoxic Tcells?
CD3, CD28, TLR CD4 and CD40 CD8
46
B cell surface proteins?
CD19, 20, 21, 40 | MHCII, B7
47
Macrophage cell surface proteins?
CD14, CD40, MHCII, B7
48
NK cells
CD16, CD56
49
Anergy?
T-cell become unreactive without stimulatory signals
50
Mech of super antigens?
Crosslink B-region of the T-cell receptor to the MHC call II on APCs
51
Macrophages can be directly (no TH cells needed) stimulated by?
Endotoxins/LPS
52
Bacteria that have antigenic variation?
Salmonella (flagella), Borrelia (recurrent fever) and gonorrhoeae (pilus)
53
Parasites with antigenic variation?
Trypanosomes (programmed rearrangement)
54
Give Passive immunity for these exposures?
To Be Healed Rapidly | Tetanus, Botulinum, HBV, Rabies
55
Purpose of viral vaccination?
decrease viral entry into cells
56
Killed vaccine
Killed and CHARed | Salik, Cholera, Hep A, Rabies
57
Immune response: live vs killed vaccine?
Cellular response vs Humoral immunity (need boosters)
58
HSR II - mechanisms?
1) opsonization 2) complement-mediated lysis 3) Ab-dependent cytotoxicity
59
Only type III HSR autoimmune Dzs? (rest are?)
SLE, Polarteritis nodosa, Post-strep GN, serum sickness and arthus reaction Rest are Type II
60
type IV HSR disorders?
Guillain-Barre, MS, PPD, contact dermatitis, Graft-vs-Host
61
Pt with no T cells - risk for?
AIDs Dzs - CMV, EBV, VZV, Candida, PCP
62
Pt with no B-cells - risk for?
GI bugs (no IgA) Encapsulated bacteria (SHiNE SKiS) Entervirals encephalitis, polio giardiasis
63
Pt with no granulocytes risk for?
``` Same as CGD - SPANkS Staph Aureus Pseudomonas Aspergillus/Candida Nocardia Serratia ```
64
Pt with no complement-risk for?
Neisseria
65
CD40L
HyperIgM
66
Pt blood stains positive for anti-myleoperoidase?
aka P-ANCA - microscropic polyangitiits
67
Pt stains positive for anti-proteinase-3 antibodies?
aka C-ANCA. Wegners
68
Marker present on all thymic cells?
CD2
69
Killed vs live vaccine: regarding Igs?
less vs more IgA
70
What occures in germinal center?
Class switching
71
HSR IV vs other HSR?
No abs. Mediated by lymphocytes only (which recruit macrophages)

2nd Time Through (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions