IMMUNO SERO

Question 1

is the study of a host’s reactions when foreign substances are introduced into the body

Answer 1

IMMUNOLOGY

Question 2

function of the immune system is to recognize self from nonself and to defend the body against nonselfsystems
responsible for the recognition and disposal of foreign (nonself ) material

Answer 2

IMMUNOLOGY

Question 3

One of the deadliest diseases known to humans

Answer 3

SMALLPOX

Question 3

a form of variolation used (in China)

Answer 3

insufflation

Question 3

study of blood serum (the clear fluid that separates when blood clots)

Answer 3

SEROLOGY

Question 4

earliest practice of variolation

Answer 4

Lady Mary
Wortley Montagu

Question 5

generally considered to be the Father of
Immunology for his use of attenuated vaccine

Answer 5

Louis Pasteur

Question 6

a phenomenon known as phagocytosis and a fundamental
part of the immune response

Answer 6

Elie Metchnnikoff

Question 7

Components of the natural immune system: Cellular

Answer 7

-Mast cells
-Neutrophils
-Macrophages

Question 8

Components of the natural immune system: Humoral

Answer 8

-Complement
-Lysozyme
-Interferon

Question 8

Components of the Adaptive Immune System: Cellular

Answer 8

-T lymphocytes
-B lymphocytes
-Plasma cells

Question 9

Components of the Adaptive Immune System: Humoral

Answer 9

-Antibodies
-Cytokines

Question 10

are molecules associated with groups of pathogens that are recognized by cells of the innate immune system.

Answer 10

PAMPs (pathogen-associated molecular patterns )

Question 11

These inflammatory components liberated from damaged cells include nucleic acids, intracellular proteins, extracellular
matrix components, oxidized lipids, crystals such as uric acids, silica, β-amyloid, and cholesterol

Answer 11

DAMPS (damage associated molecular patterns)

Question 12

The receptors of the innate immune system that recognize these PAMPs are called

Answer 12

pattern recognition receptors (PRRs)

Question 13

Three groups of PRRs exist

Answer 13

• Secreted PRRs
• Phagocytosis receptors
• Toll-like receptors (TLRs)

Question 14

type of adaptive immunity

Answer 14

• antibodies from mother to child
  *immunoglobulins for rabies infection
• attenuated vaccines
• Toxoids
• Convalescence plasma treatment

Question 15

a substance that stimulates antibody
formation

Answer 15

antigen

Question 16

ability to bind to an antibody or a
T lymphocyte antigen receptor but may not be able to evoke
an immune response initially.

Answer 16

antigen

Question 17

all immunogens are antigens but not all
antigens are immunogens

Answer 17

true

Question 18

PHYSICAL CHARACTERISTICS

Answer 18

• Foreignness
• Degradability
• Molecular Weight
• Structural Stability
• Complexity

Question 19

CHEMICAL NATURE

Answer 19

large organic molecules that are proteins or large polysaccharides and,
rarely, if ever, lipids.

Question 20

excellent antigens because of their high molecularweight and
structural complexity

Answer 20

protein

Question 21

considered inferior antigens because of their relative simplicity and lack of structural stability.

Answer 21

lipids

Question 22

poor antigens because of relative simplicity, molecular mflexibility, and rapid degradation

Answer 22

nucleic acids

Question 23

combination of biochemical classes

Answer 23

Glycolipids and glycoproteins (HLA)

Question 24

part of an antigen, reacts specifically with an antibody or T lymphocyte receptor.

Answer 24

epitope

Question 25

antigenic but are not immunogenic

Answer 25

HAPTENS

Question 26

immunogenic

Answer 26

hapten+ carrier protein

Question 27

Cellular antigens of importance include histocompatibility antigens, autoantigens, and blood group antigens

Answer 27

ENDOGENOUS ANTIGEN

Question 28

intracellular pathogens

Answer 28

ENDOGENOUS ANTIGEN

Question 29

APC - T HELPER CELL( CD4) - MHC II

Answer 29

EXOGENOUS ANTIGEN (OUTSIDE )

Question 30

Cellular antigens of importance include histocompatibility antigens, autoantigens, and blood group antigens

Answer 30

ENDOGENOUS ANTIGEN

Question 31

Ag found on the membranes of almost all the cells of human body

Answer 31

Major Histocompatability Antigens

Question 32

targets of T lymphocytes that regulate the immune response

Answer 32

Both class I and class II antigens function

Question 33

Also known as “immunoglobulin”

Answer 33

ANTIBODY

Question 34

glycoproteins found in the serum portion of the blood, constitute approx. 20% of plasma proteins.

Answer 34

antibody

Question 35

Serum electrophoresis

Answer 35

proteins are separated out on the basis of size and charge

Question 36

All immunoglobulin molecules are made up of a basic four chain tetrapeptide unit that consist of

Answer 36

* 2 large chain called heavy or H chain * 2 smaller chains called light or L chains

Question 37

proteolytic enzymes used to cleaved Antibody structres

Answer 37

-Papain -pepsin

Question 38

Present in blood, plasma, and tissue fluids

Answer 38

Immunoglobulin G

Question 39

Normal human adult serum values of IgG

Answer 39

800 to 1800 mg/dL (90 to 210 IU/mL)

Question 40

the longest of all of the Ig isotypes

Answer 40

IgG

Question 41

The ability of a particular antibody to combine with a particular antigen

Answer 41

Specificity

Question 42

occurs between bacteria that possess the same cell wall polysaccharides as mammalian erythrocytes

Answer 42

Cross-reactivity