immunology

Question 1

what is the cause of myasthenia gracis

Answer 1

90% idiopathtic 10% thymus tumours

Question 2

how does MG occur

Answer 2

an autoimmune respnse of igG antibodies binding with ACH on muscle cells meaning normal signal cant bind to neurotransmitter so theres no contraction

Question 3

what does MG usually effect

Answer 3

face muscles - low pitched voice, sore swallowing, ocular muscles, fatigues and progressive muscle weakness

Question 4

investigation of MG

Answer 4

presence of anti AChR IgG in serum repetitive nerve stimulation

Question 5

management of MG

Answer 5

rest, anti cholinesterase (pyridostigmine), surgery (thymectomy), immunosuppressive drugs

Question 6

what type of reaction MG

Answer 6

type 2

Question 7

what musxles does MG effect

Answer 7

only skeletal muscle

Question 8

how to improve MG

Answer 8

its chronic and progressive but rest can improve it - by allowing time for receptors to return to the surface

Question 9

what alleles are strongly associated with RA

Answer 9

DRB1 alleles

Question 10

what is a risk factor for citrinoliation

Answer 10

smoking

Question 11

what type of reaction is RA

Answer 11

usually type 4 but some type 3

Question 12

diagnosis of RA

Answer 12

serum presve of RF or anti CCP antibodies, inflammatory markers and X rays of hands and feet

Question 13

treatnent of RA

Answer 13

immunosuppression and biologic therapies