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Flashcards in Immunology Deck (35)
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1

what mediates type 1 hypersensitivity reactions

IgE
- allergy

2

what mediates type 2 hypersensitivity reactions

Complement (IgG or IgM)
- cytotoxic
- antibody dependent

3

what mediates type 3 hypersensitivity reactions

IgG complement, neutrophils
- immune complex mediated

4

what mediates type 4 hypersensitivity reactions

T cells
- delayed hypersensitivity

5

what type of reaction are eczema, hives and hay fever

type one

6

what type of reaction is SLE

Type 3

7

what type of reaction is ABO mismatch

Type 2

8

what type of reaction is RA

Type 3

9

what type of reaction is contact dermatitis

Type 4

10

what type of reaction is a graft rejection

Type 4

11

primary lymphoid tissue

bone marrow + thymus

12

secondary lymphoid tissue

spleen + tonsils

13

proteins in innate immune system

complement
acute phase proteins
cytokines

14

proteins in adaptive immune system

antibodies
cytokines

15

leukocytes in adaptive immune system

B lymphocytes
T lymphocytes

16

leukocytes in innate immune system

macrophage
neutrophils
dendritic cells
basophils
eosinophils
NK cells

17

opsonins that enhance phagocytosis

C3b
collectins
CRP

18

interferons

anti-viral activity

19

TNF alpha

pro- inflammatory cytokine

20

what interleukin activates CD8 T cells

IL 2

21

antibody found in breast milk, saliva, tears

IgA

22

antibody that provide maternal immunity

IgG

23

first antibody produced in acute infection

IgM

24

what does MHC 1 present to

CD8 T cells

25

what does MHC 2 present to

CD4 T cells

26

what is deficient in chronic granulomatous disease
what are the symptoms

NADPH oxidase - failure of oxidative killing
- recurrent pneumonias + abscesses

27

what is the most common primary antibody deficiency

selective IgA deficiency

28

features of selective IgA deficiency

recurrent sinus + resp infections
associated with coeliac disease

29

features of X linked (Burtons) congenital agammaglobulinaemia

recurrent bacterial infections
- absent B cells
- reduction in ALL immunoglobulins

30

features of severe combined immunodeficiency

X linked
- recurrent VIRAL, BACTERIAL + FUNGAL infections
- failure to produce lymphocytes
- IL2 mutation
- presents after 3 months of life- diarrhoea, failure to thrive