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Flashcards in Pharmacology Deck (22)
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1

what is the principal organ of drug excretion

kidney

2

what is acid's relationship with protons

acid donates protons

3

what is base's relationship with protons

bases accept protons

4

Henderson hasslebach equation for acids

pKa - pH = log(AH/A-)

5

Henderson hasslebach equation for bases

pKa - pH = log(BH+/B)

6

what facilitates the absorption of weak acids

pH of stomach lumen

7

where are bases absorbed

small intestine

8

what form of drug moves readily by diffusion

unionised drugs

9

what is the reducing agent in a reaction

the one that is oxidised i.e. the one that loses electrons

10

what is the oxidising agent in a reaction

the one that is reduced i.e. gains an electron

11

what drugs can cause hyperkalaemia

ACE/ARBs
spironolactone
NSAIDs

12

what is Km

concentration at which drug works at half of Vmax

13

what is Vmax

concentration at which the drug is having maximal effect

14

effect of rifampicin on ethylestriadol

unchanged Km and higher Vmax

15

sildenafil and isosorbide mononitrate leads to what

postural hypotension

16

what can exacerbate gout when px is on allopurinol

furosemide

17

pain relief in OA if patient is on warfarin

paracetamol

18

tx paracetamol overdose

IV N acetylcysteine

19

how long before surgery does warfarin need to be stoped

5 days

20

does omeprazole need to be used with caution in patients with impaired renal function

no

21

when is steady state plasma concentration achieved for a drug with first order kinetics

when the rate of administration equals rate of elimination

22

what does knowledge of volume of distribution help you calculate

loading dose